Tumor suppressor genes Flashcards
1
Q
RB
A
Associated tumor:
Retinoblastoma, osteosarcoma
Gene products:
Rb gene products blocks G1 –> S phase of the cell cycle
2
Q
p53
A
Associated tumor:
Most human cancers, Li-Fraumeni syndrome
Gene products:
p53 gene product blocks G1 –> S phase of the cell cycle
3
Q
BRCA1
A
Associated tumor:
Breast and ovarian cancer
Gene products:
DNA repair protein
4
Q
BRCA2
A
Associated tumor:
Breast cancer
Gene products:
DNA repair protein
5
Q
p16
A
Associated tumor:
Melanoma
6
Q
APC
A
Associated tumor: Colorectal cancer (associated with FAP)
7
Q
WT1
A
Associated tumor:
Wilm’s tumor
8
Q
NF1
A
Associated tumor:
Neurofibromatosis type 1
9
Q
NF2
A
Associated tumor:
Neurofibromatosis type 2
10
Q
DPC
A
Associated tumor:
Pancreatic cancer
DPC = Deleted in Pancreatic Cancer
11
Q
DCC
A
Associated tumor:
Colon cancer
DCC = Deleted in Colon Cancer
