Oncogenes

Question 1

abl

Answer 1

Associated disorder:
CML

Gene product:
Tyrosine kinase

Question 2

c-myc

Answer 2

Associated disorder:
Burkitt’s lymphoma

Gene product:
Transcription factor

Question 3

bcl-2

Answer 3

Associated disorder:
Follicular and undifferentiated lymphomas (inhibits apoptosis)- of B cells

Gene product:
Anti-apoptotic molecule

Question 4

erb-B2

Answer 4

Associated disorder:
Breast, ovarian, and gastric carcinomas

Gene product:
Tyrosine kinase

Question 5

ras

Answer 5

Associated disorder:
Colon carcinoma

Gene product:
GTPase

Question 6

L-myc

Answer 6

Associated disorder:
Lung tumor

Gene product:
Transcription factor

Question 7

N-myc

Answer 7

Associated disorder:
Neuroblastoma

Gene product:
Transcription factor

Question 8

ret

Answer 8

Associated disorder:
Multiple endocrine neoplasia (MEN) types IIA and IIB

Gene product:
Tyrosine kinase

Question 9

c-kit

Answer 9

Associated disorder:
Gastrointestinal stromal tumor (GIST)

Gene product:
Cytokine receptor