Tumor markers

Question 1

alkaline phosphatase

Answer 1

metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)

Question 2

a-fetoprotein

Answer 2

hepatocellular carcinoma, hepatoblastoma, yolk sac tumor, testicular cancer, mixed germ cell tumor (co-secreted with b-HCG)

Question 3

beta-HCG

Answer 3

Hyatidiform moles and Choriocarcinomas (Gestational trophoblastic diseaese), testicular cancer

Question 4

CA-15-3-/CA-27-29

Answer 4

breast cancer

Question 5

CA-19-9

Answer 5

pancreatic adenocarcinoma

Question 6

CA-125

Answer 6

ovarian cancer. remember mommy got this tested.

Question 7

calcitonin

Answer 7

medullary thyroid carcinoma

Question 8

CEA

Answer 8

CarcinoEmbryonic Antigen. very nonspecific but produced by 70% of colorectal and pancreatic cancers, also produced by gastric, breast and medullary thyroid carcinomas

Question 9

PSA

Answer 9

prostate-specific Ag. follow prostate adenocarcinoma. can also be high in BPH and prostatitis.

Question 10

S-100

Answer 10

neural crest origin (melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)

Question 11

TRAP

Answer 11

tartrate-resistant acid phosphatase (TRAP) - hairy cell leukemia (B cell neoplasm)