Tumor markers Flashcards by Brian Andrew

AFP

Hepatocellular carcinoma
Hepatoblastoma
Yolk sac (endodermal sinus) tumor
Testicular cancer
Mixed germ cell tumor (co-secreted with beta-hCG)

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CA-19-9

Pancreatic adenocarcinoma

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CA-125

Ovarian cancer

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Calcitonin

Medullary thyroid carcinoma

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Calretinin (Vit D-depending Ca-binding protein)

Mesothelioma

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CEA

Colon cancer (good for assessing treatment response)
Pancreatic cancer

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CD34, CD117

GIST

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Chromogranin

Neuroendocrine tumor

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Desmin

Smooth muscle and skeletal muscle sarcomas

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Glial fibrillary acidic protein (GFAP)

Glioma (astrocytoma, ependymoma)

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hCG

Gestational trophoblastic disease (hydatidiform moles and choriocarcinomas)
Testicular cancer

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Inhibin

Sex cord-gonadal stromal tumor

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PSA

Prostate cancer

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Thyroglobulin

Post-operative marker of thyroid cancer (but not medullary thyroid cancer)

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Alkaline phosphatase

Metastases to bone or liver
Paget disease of bone
Seminoma (placental ALP)

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CA-15-3/CA-27-29

Breast cancer

S-100

Neural crest origin (e.g. melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)

TRAP (Tartate-Restistant Acid Phosphatase)

Hairy cell leukemia