Endo & Repro pathology Flashcards
Lichen sclerosis
Thinning of the epidermis and fibrosis of the dermis
Presents as leukoplakia with parchment-like vulvar skin
Post-menopausal women
Increased risk for SCC (unlike lichen simplex chronicus
Lichen simplex chronicus
Hyperplasia of the vulvar squamous epithelium
Presents as leukoplakia with thick, leathery vulvar skin
Associated with chronic irritation and scratching
No increased risk of SCC (unlike lichen sclerosis)
Extramammary paget disease
Malignant epithelial cells in the epidermis of the vulva
Presents as erythematous pruiritic ulcerated vulvar skin
Carcinoma in situ, WITHOUT underlying carcinoma (unlike Paget disease of the nipple that is almost always associated with underlying carcinoma)
Paget cells are PAS+ (mucus), keratin+ (intermediate filament in epithelial cells), and S100- (marker of melanoma) vs melanoma which is PAS-, keratin-, S100+
Effects of diethylstilbestrol (DES)
DES is an estrogen-like compound that was used to treat pregnancy-related complications.
In female infants, it caused adenosis (persistence of columnar epithelium in upper vagina), clear cell adenocarcinoma, and abnormal shaped uteri and fallopian tubes
In mothers, it increased risk of breast carcinoma
No effect on male infants
Tumors with psammoma bodies
- Papillary carcinoma of the thyroid
- Meningioma
- Serous endometrial carcinoma
- Mesothelioma
- Serous cystadenocarcinoma (BRCA1)
Treatment of endometritis
Gentamicin + clindamycin +/- ampicillin
Brenner tumor
Benign ovarian tumor with bladder-like surface epithelium
Coffee-bean nuclei on H&E
Meigs syndrome
Triad of ovarian fibroma, ascites, and pleural effusion
Pulling sensation in the groin
Serous cystadenocarcinoma
Most common ovarian neoplasm. Frequently bilateral
Most commonly arises in postemenopausal women (cystadenomas are more common in premenopausal women)
BRCA1 mutation increases risk of serous carcinoma of the ovary and fallopian tube
Characterized by psammoma bodies
Pseudomyxoma peritonei
Intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor
Mature cystic teratoma (dermoid cyst)
Germ cell tumor that contains elements from all 3 germ layers; most common ovarian tumor in women 20-30 years old
Benign in women and children, malignant in men
Presents secondary to pain secondary to ovarian enlargement or torsion
hCG or AFP may be elevated
Struma ovarii - dermoid cyst that contains functional thyroid tissue
Immature teratoma
Malignant ovarian tumor; more aggressive than benign mature cystic teratoma (dermoid cyst)
Presence of immature tissue (fetal tissue, neuroectoderm) and somatic malignancy (SCC of skin) indicate malignant potential
Dysgerminoma
Most common malignant germ cell tumor
Composed of large cells with clear cytoplasm and central nuclei (resemble oocytes)
Equivalent to seminomas in males
Elevated LDH
Good prognosis, responds to radiotherapy
Yolk sac (endodermal sinus) tumor
Aggressive malignant ovarian/testicular neoplasm
Common in children (ovaries, testes, sacrococcygeal area)
Elevated AFP
Shiller-Duval bodies (glomerulus-like structures) characteristic
Choriocarcinoma
Malignant ovarian/testicular carcinoma consisting of cytotrophoblasts and syncytiotrophoblasts
Villi are ABSENT
Hemorrhagic tumor with early hematogenous spread to lungs (hemoptysis)
High beta-hCG (may lead to theca-lutein cysts, hyperthryoidism, gynecomastia)
Good response to chemo when it arises from gestational pathway (spontaneous abortion, normal pregnancy, hydratidiform mole); poor response to chemo when it arises from a spontaneous germ cell pathway
Krukenberg tumor
Metastatic mucinous signet cell adenocarcinonma that most commonly arises from diffuse subtype of gastric carcinoma
Differentiated from primary mucinous ovarian tumors by bilaterality of Krukenberg tumor
Preeclampsia
Usually arises in third trimester
Characterized by fibrinoid necrosis in vessels of placenta
HELLP - preeclampsia with thrombotic microangiopathy; characterized by Hemolysis, Elevated Liver enzymes, and Low Platelets
Tx of HTN in pregnancy: alpha-methyldopa, labetolol, hydralazine, nifedipine
Kallman syndrome
Form of hypogonadotropic hypogonadism caused by defective migration of GnRH cells and defective formation of olfactory bulb
Results in decreased synthesis of GnRH and anosomia
Lymphogranuloma venereum
Necrotizing granulomatous inflammation of the inguinal lymphatics and LNs caused by Chalmydia (serotypes L1-L3)
Heals with fibrosis
Serotypes of Chlamydia trachomatis
- A - C — cause trachoma: infection of the eyes, which can lead to blindness
- D - K — cause urethritis, PID, ectopic pregnancy, neonatal pneumonia, and neonatal conjunctivitis
- L1 - L3 — lymphogranuloma venereum
Bowen disease
In situ SCC of the penile shaft or scrotum
Presents as leukoplakia
Erythroplasia of Queyrat
In situ SCC of the glans fo the penis
Presents as erythroplakia
Bowenoid papulosis
In situ SCC that presents as multiple reddish penile papules
Unlike Bowen disease and Erythroplakia of Querat, it does not progress to invasive carcinoma
Orchitis
Inflammation of the testicle
Causes:
- Chlamydia (types D-K), N. gonorrhea - young adults; also cause prostatitis
- E. coli, Pseudomonas - older adults post-UTI; also causes prostatitis
- Mumps virus
- Autoimmune orchitis - granulomas involving seminiferous tubules