Tumor Markers Flashcards
1
Q
Alkaline Phosphatase
A
Metastases to bone,
liver,
Paget disease of bone,
seminoma (placental ALP).
2
Q
alpha-fetoprotein
A
HCC Hepatoblastoma Yolk sac (endodermal sinus) tumor Testicular cancer Mixed germ cell tumor (co-secreted with beta-hCG)
3
Q
beta-hCG
A
Hydatidiform moles
Choriocarcinomas (gestational trophoblastic disease)
Testicular cancer
4
Q
CA-15-3/CA-27-29
A
Breast cancer
5
Q
CA-19-9
A
Pancreatic adenocarcinoma
6
Q
CA-125
A
Ovarian cancer
7
Q
Calcitonin
A
Medullary thyroid carcinoma.
8
Q
CEA
A
Carcinoembryonic antigen.
Nonspecific but 70% of colorectal and pancreatic cancers
Also gastric, breast, medullary thyroid
9
Q
PSA
A
Prostate-specific antigen.
10
Q
S-100
A
Neural crest origin (e.g. melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)
11
Q
TRAP
A
Tartrate-Resistant Acid Phosphatase.
Hairy cell leukemia (B Cell neoplasm)
