Cytokines Flashcards
IL-1
Macrophage:
Pyrogen –> fever.
Endothelium to express adhesion molecules –> induce chemokine secretion to recruit leukocytes.
IL-2
T Cell:
Stimulates growth of helper, cytotoxic, and regulatory T cells.
IL-3
T Cells:
Supports growth and differentiation of bone barrow stem cells. Functions like GM-CSF.
IL-4
Th2 Cells:
Induces differentiation into Th2 cells.
Promotes growth of B cells.
Class switching to IgE and IgG.
IL-5
Th2 Cells:
Promotes differentiation of B cells.
Class switching to IgA.
Stimulates growth and differentiation of eosinophils.
IL-6
Macrophages:
Endogenous pyrogen.
Also secreted from Th2 cells.
–> causes fever and stimulates production of acute-phase proteins.
IL-8
Macrophages:
Chemoattractant for neutrophils.
IL-12
Macrophages:
Differentiation of T cells to Th1 cells.
Activates NK cells.
Also secreted by B cells.
TNF-alpha
Macrophages:
Mediates septic shock.
Activates endothelium.
Causes leukocyte recruitment, vascular leak.
Interferon-gamma
Th1 Cells:
Has antiviral and antitumor properties.
Activates NK cells to kill virus-infected cells.
Increases MHC expression and antigen presentation in al cells.
IL-10
Th2 Cells:
Modulates inflammatory response.
Inhibits Actions of activated T Cells and Th1.
Secreted by T regulatory cells.
TGF-beta
Similar to IL-10. Inhibits inflammation.
Interferon alpha and beta
Innate defense against viruses.
Primes local uninfected cells (paracrine signaling).
If viral dsRNA, activates:
-RNAse L –> Degrade viral/host mRNA.
-Protein kinase –> inhibit viral/host protein synthesis.
