Autoantibodies

Question 1

Anti-Ach

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasteur’s syndrome

Question 3

Anti-cardiolipin, lupus anticoagulant

Answer 3

SLE; antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome)

Question 5

Anti-desmoglein

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

Anti-glutamate decarboxylase

Answer 7

T1DM

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigus

Question 9

Antihistone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Antimicrosomal, antithyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

Primary biliary cirrhosis

Question 13

Antinuclear antibodies

Answer 13

SLE (non-specific)

Question 14

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 14

Scleroderma (diffuse)

Question 15

Anti-smooth muscle

Answer 15

Autoimmune hepatitis

Question 16

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 16

Sjogren syndrome

Question 17

Anti-TSH receptor

Answer 17

Grave’s disease

Question 18

Anti-U1 RNP (ribonucleoprotein)

Answer 18

Mixed connective tissue disease

Question 19

c-ANCA (PR3-ANCA)

Answer 19

Granulomatosis with polyangiitis (Wegener)

Question 20

IgA antiendomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac disease

Question 21

p-ANCA

Answer 21

Microscopic polyangiitis, Churg-Strauss syndrome

Question 22

Theumatoid factor (antibody, mostly commonly IgM, specific to IgG Fc region), anti-CCP

Answer 22

Rheumatoid arthritis