Tumor Markers

Question 1

This is found in tissues and serves as marker for malignancies

Answer 1

Tumor Markers

Question 2

Marker for epithelial tissue cells and used for diagnosis of carcinoma

Answer 2

Keratin

Question 3

Malignancy that is epithelial in origin

Answer 3

Carcinoma

Question 4

Malignancy that is connective tissue origin

Answer 4

Sarcoma

Question 5

Can determine the site of tumor. Useful in detecting (breast) adenocarcinoma. (+) In Breast, lung, and Kidney cancer

Answer 5

Epithelial
Membrane
Antigen (EMA)

Question 6

This is an oncofetal antigen

Answer 6

Carcinoembryonic
antigen (CEA)

Question 7

This differentiates adenocarcinoma from mesothelioma

Answer 7

Carcinoembryonic
antigen (CEA)

Question 8

CEA is elevated in cancers of?

Answer 8

Cancers of Gastrointestinal Tract

Question 9

CEA is also used in monitoring of cancers in: (4)

Answer 9

Colon
Pancreas
Cervix
Breast cancer

Question 10

Differentiates lung adenocarcinoma from
mesothelioma

Answer 10

Thyroid Transcription Factor 1 (TTF-1)

Question 11

Found in thyroid neoplasm/ cancer

Answer 11

Thyroid Transcription Factor 1 (TTF-1)

Question 12

Highly specific antigen for prostate

Answer 12

Prostate Specific Antigen (PSA)

Question 13

PSA is eleveted in? (4)

Answer 13

1. Prostate cancer
2. Pancreatic cancer
3. Salivary tumors
4. Prostate infection

Question 14

Normally found in breast epithelial cells, but
not in myoepithelial cells

Answer 14

Estrogen-Progesterone
Receptor (ER/PR)

Question 15

Purpose of ER/PR: (2)

Answer 15

1. Very useful in determining prognosis and treatment of breast cancer/ carcinoma and identification of metastatic breast carcinoma
2. Determination of prognosis is useful especially
   when the px is undergoing chemotherapy

Question 16

Prognosis of positive in ER/PR

Answer 16

Good prognosis