Tumor Immunology Flashcards
Where does leukemia develop and what are the main types?
Develops in the bone marrow
- acute lymphoblastic leukemia
- acute myeloid leukemia
- chronic lymphocytic leukemia
- chronic myeloid leukemia
Where does lymphoma develop and what are the 2 main types:
Develops in the lymphatic system
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
What are myelomas?
Tumors of plasma cells
Post transplant lymphoma is particularly associated with infection by?
EBV
A patient presents with large numbers of mature B cells in their serum. What is most likely the diagnosis?
CLL
A paraprotein was detected on a electrophoretic gel during testing of a patient. What is the Pathogenesis that leads to its presence?
Malignant plasma cells produce monoclonal antibody of a single specificity
Cells described as ‘K’ (killer) cells mediate?
ADCC
What type of tumor would you expect a patient to present with if they had a mutation in a cellular gene that is not involved in tumorigenesis?
Melanoma
Which immune cell may be responsible for down regulating the anti tumor response?
MDSC
NK cell inhibitory receptors recognize?
MHC Class 1
Why is it beneficial that NK cells have both inhibitory abs activating receptors?
Inhibitory receptors ensure that NK cells do not attack self
Activating receptors ensure that NK cells can attack damaged/abnormal cells that express MHC
Denileukin difitox targets?
CD25
IFNα can be used to treat?
CML
karposi sarcoma
Hairy cell leukemia
Melanoma
Transfection of a patients lymphocytes with a CAR gene results in?
More efficient tumor antigen recognition with addition of gene sequences that will aid in the destruction of tumor cells
What are prophylactic vaccines?
A prophylactic, or preventative, vaccine involves introducing antigens into a person’s body. The goal is that the individual’s immune system will create antibodies for those antigens, and become immune to the associated illness.
