Adaptive Immune System- Lymphocyte Recirculation and Homing

Question 1

Why do lymphocytes recirculate?

Answer 1

To seek out their antigens

Question 2

Which combination of cells need to interact in order to mount an adaptive immune response?

Answer 2

Dendritic T cells, Helper T cells and B cells specific for the same antigen

Question 3

What do high endothelial venules allow the lymphocytes to do?

Answer 3

Bypass the lymphatic circulation and enter the lymph nodes directly

Question 4

What are chemokines?

Answer 4

Chemotactic cytokines but with multiple other effects

Question 6

What can T cells be divided into after they’ve encountered an antigen?

Answer 6

Central memory T cells

Effector memory T cells

Question 7

Name 3 features of Cell Adhesion Molecules (CAMs)

Answer 7

1. Promote cell-cell and cell-extracellular matrix interactions
2. Can be expressed constitutively or induced by pathogen and host products during inflammation
3. Homophillic or heterophillic reactions

Question 8

What are the 5 main groups of CAMs?

Answer 8

1. Cadherins
2. Ig-superfamily CAMs
3. Mucin like CAMs
4. Selectins
5. Integrins

Question 9

What are the 4 families of chemokines(grouped according to arrangement of cysteines in structure)?

Answer 9

C family
CC family
CXC family
CX3C family

Question 10

What are vascular addressins?

Answer 10

Cell adhesion molecules specific to different parts of the body which activated T cells can recognize in order to return to the site of infection