Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immuno Exam 2 > Tumor Immunology > Flashcards

Tumor Immunology Flashcards

1
Q

carcinoma

A

epithelial cells, most common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

sarcoma

A

muscle cells, fat cells, fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

lymphoma

A

solid tumors of lymphoid tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

leukemias

A

lymphocytes and other hematopoietic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

tumor specific antigens TSA

A

antigens unique to a particular tumor and not present on normal cell types, arise from point mutations or gene rearrangements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

tumor associated antigens TAA

A

antigens shared by different tumors but also found in normal tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

examples of tumor associated antigens

A
  • oncofetal antigens: expressed on fetus but not adult tissues
  • alpha fetal protein: liver cancer
  • carcinoembryonic antigen CEA: colon cancer, smokers
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

oncogenic viral antigens

A 
occur on some DNA/RNA viruses
tumors and viral antigens on class I MHC
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

pre b cell tumors express

A

CD10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T cell leukemias express

A

CD4, CD8, TCR, IL-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

B lymphocytes

B cell leukemias and lymphomas express

A

CD10 (CALLA)

Immunoglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T lymphocytes

T cell leukemias and lymphomas express

A

IL-2 receptor alpha chain
T cell antigen receptor
CD45R
CD4/CD8 markers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Prostate

Prostatic carcinoma

A

prostate specific antigen

prostatic acid phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

neural crest derived tissue

melanomas

A

S-100

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Epithelial Cells

carcinomas

A

cytokeratins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

cytotoxic t lymphocytes

A

produced against carcinomas, sarcomas, and virus induced tumors

17
Q

natural killer cells

A

lyse tumors of hematopoeitic origin and virus induced

activating signal= downregulation of Class I MHC

INF, TNF-a, IL-2 enhance NK cells to lyse

18
Q

macrophages

A

kill tumor cells via ADCC or TNF-a (free radicals)

19
Q

immunosupressive substances in tumor evasion

A

TGF-B

20
Q

radiotherapy

A

destroys rapidly dividing cells

21
Q

chemotherapy

A

inhibits DNA replication, RNA transcription, or protein synthesis

22
Q

Melanoma MAGE antigens

A

induce CTLs

23
Q

Hepatitis B vaccine

A

decrease incidence of hepatoceullular carcinoma

24
Q

Herceptin (Trastuzumab)

A

targets HER-2/neu growth factor receptor
blocks receptor-ligand interaction
decreases expression of HER-2/neu

25
Q

Lymphokine activated killer cell therapy LAK

A

peripheral blood NK cells cultured in IL-2–>LAK cells

LAK cells get reinfused into the patient

26
Q

Tumor infiltrating lymphocyte therapy TIL

A

leukocytes from solid tumors cultured with IL-2 and given to the patient

27
Q

cytokine therapy

A

IL-2 given to generate LAK cells and activate CTLs

TNFa

28
Q

IFNa

A

tumor antiproliferative effects
increase NK cell activity
increase class I MHC expression on tumor cells

Immuno Exam 2 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions