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Immuno Exam 2 > Autoimmunity > Flashcards

Autoimmunity Flashcards

1
Q

autoimmune hemolytic anemia

A

RBC antibodies against RBC membrane proteins

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2
Q

goodpasteurs syndrome

A

autoantibodies to the a3 chain of type IV collagen

causes complement activation

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3
Q

pernicious anemia

A

autoantibodies to intrinsic factor or parietal cells
decrease absorption of vitamin B12
leads to abnormal erythropoiesis and anemia

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4
Q

Hashimoto’s thyroiditis

A

HYPOthyroid

autoantibodies and auto reactive T cells to thyroid gland proteins

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5
Q

idiopathic thrombocytopenia purpura ITP

A

platelets destroyed by autoantibodies to platelet membrane proteins

IVIG can prevent destruction

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6
Q

Vitiligo

A

depigmentation of skin via destruction of melanocytes

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7
Q

Grave’s disease

A

autoantibodies against the TSH receptor

HYPERthyroidism

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8
Q

Myasthenia Gravis

A

autoantibodies to a chain of nicotinic acetylcholine receptor

causes muscle weakness and paralysis

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9
Q

Type 1A diabetes

A

autoantibodies to B cells

autoreactive T cells mediate destruction of B cells

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10
Q

multiple sclerosis

A

TH1 and TH17 myelin antigens become activated

damage myelin containing nerve cells

therapy= INFB1b, INFB1a, IV steroids

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11
Q

systemic lupus erythematosus SLE

A

autoantibodies against antigens like DNA, RNA, proteins, and ribonucleoproteins

most tissue injury via immune complexes

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12
Q

SLE big danger

A

kidney failure due to the passage of immune complexes through the glomerulus

deposition of podocytes that express CR1 that binds C3b and C4b on the immune complexes

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13
Q

Rheumatoid arthritis

A

HLA-DR4 haplotype

TH1 and TH17, macrophages, B cells and plasma cells

rheumatoid factor–> IgM/IgG to Fc of IgG–> immune complexes

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14
Q

ethanercept

rheumatoid arthritis

A

TNF a type II receptor fused to IgG1 antibody

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15
Q

Infliximab

rheumatoid arthritis

A

chimeric mouse/human anti TNF a monoclonal antibody

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16
Q

adalimumab

rheumatoid arthritis

A

recombinant human IgG1 monoclonal

17
Q

scleroderma

A

release of IL-1 and TNF-a which produces collagen

excessive deposition of collagen in skin, kidneys, GI, heart, muscles, lungs

possible hypersensitivity rxn to collagen

18
Q

polymyotisis dermatomyotosis

A

muscle injury due to CD4 and CD8 t lymphocytes

autoantibodies to histidyl tRNA synthase

19
Q

cyclosporine and tacrolimus

A

block calcineurin activity

blocks transcription of IL-2

20
Q

plasmapheresis

A

removes Ag-Ab complexes gives a short term alleviation of symptoms

Immuno Exam 2 (8 decks)

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