tumor, headache, dementia, Parkinson Flashcards
Adult primary brain tumors - types
- Glioblastoma multiforme (grade IV astrocytoma)
- Meningioma
- Hemangioblastoma
- Schwannoma
- Oligodendroglioma
- Pituitary adenoma
Meningioma - treatment / histology
resection and/or radiosurgery
- spindle cells concentrically arranged in a whorled pattern
- psammoma bodies (laminated calcification)
Hemangioblastoma - most often area / can produce
cerebellum / erytrhopoietin (2ry polycethemia)
- associated with VHL
Schwannoma stain / treatment
S-100 positive
- resectable or treated with stereotactic radiosurgery
Childhood primary brain tumors - types
- Pilocytic (low grade) astrocytoma
- Medulloblastoma
- Ependymoma
- Craniopharyngioma
- pinealoma
ependymoma can cause / histology
Hydrocephalus
- characteristic perivascular rosettes.
Rod-shaped blepharoplasts (basal ciliary bodies) found near nucleus
craniopharyngioma can cause
- bitemporal hemianopia
- hypopituitarism
- hyperphagia (destruction of ventromedial area - satiety area of hypothalamus)
Medulloblastoma - histology / gross appearance / complications
- Homer-Wright rosettes
- small blue cells
gross: solid
complications: 1. compress 4th ventricle causing hydrocephalus - send “drop metastases” to spinal cord
Pinelioma can cause … (and mechanism)
- Parinaud syndrome: compression of tectum –> vertical gaze palsy
- obstructive hydrocephalus (compression of cerebral aqueduct)
- precosious puberty in males (increased β-HCG production)
headache - definition / MC in (sex)
- pain due to irritation of of structure such as dura, cranial nerves or extracranial structures
- MC in women, except clusters
main types of headache - duration
- cluster –> 15min-3h repetitive
- tension –> more than 30 min (typically 4-6h)
constant - migraine –> 4-72h
Migraine mnemonic
POUND
Pulsatile, One-day duration, Unilateral, Nausea, Disabling
cluster headache - characteristic of pain and other symptoms
- Repetitive brief headaches
- Excruciating periorbital pain with lacrimation
- Rhinorrhea
- may present with HORNER syndrome
cluster headache - treatment
acute: 1. 100% 02 2. sumatriptan
prophylaxis: verapamil
tension headache - treatment
- Analgesics
- NSAID
- acetaminophen
- Amitryptyline for chronic pain
Migraine - treatment
Acute: triptans, NSAIN, dihydroergotamine
ProphylaxiS: lifestyle changes (sleep, exercisem diet eg,) propranolol, topiramate, Ca2+ channel blockers, amitriptyline, valproate
triptans - clinical use
- acute migraine
2. cluster headache attacks
triptans - mechanism of action
5-HT (1B/1D) agonists (seretonin) –>
a. inhibit trigeminal nerve activtion
b. prevent vasoactive peptide release
c. induce vasoconstriction
triptans - toxicity
- coronary vasospasm
2. mild paresthesia
triptans are contraindicated in
patients with CAD or Prinzmetal angina
Menierre disease - symptoms
- recurrent attacks of vertgio (>20 mins)
- tinnitus
- hearing loss
- fullness sensation
familiar form of Alzheimer disease - proportion and proteins
10%
APP, presenilin-1, presenilin-2
Altered proteins - Alzheimer disease
altered proteins:
ApoE2: decreased risk of sporadic
ApoE4: increased risk of sporadic
APP: increased risk for early onset (familiar)
presenilin-1: increased risk for early onset (familiar)
presenilin-2: increased risk for early onset (familiar)
Alzheimer disease - histology
- loss of ach neurons
- senile plaques in gray matter (extracellular β-amyloid (Aβ) core)
- Neurofibrillary tangles (intracellular, hyperphosphorylated tau protein)