Tubular excretion Flashcards

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1
Q

Where does it take place?

A

Proximal and distal tubules of nephron

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2
Q

What takes place?

A

Cells of the tubules remove certain molecules and ions fro blood and actively deposit into the filtrate

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3
Q

Which ions move into the filtrate?

A

Hydrogen ions and potassium ions

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4
Q

What happens to the sodium ions?

A

Move back into the blood

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5
Q

What follows the sodium ions?

A

Water by osmosis

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6
Q

What other substances move into the filtrate?

A

Creatinine and uric acid

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7
Q

What happens to undesirable substances?

A

Actively excreted

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8
Q

What are undesirable substances?

A

Drugs, preservatives and colourants

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9
Q

Define PH

A

Measure of the hydrogen ion concentration in a solution – measure of acidity or alkalinity

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10
Q

What are large numbers of hydrogen ions produced by?

A

Metabolism

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11
Q

What does metabolism due to the pH?

A

Low is the pH

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12
Q

Why is it important that we have buffet systems?

A

To ensure pH remains in range in which the enzyme can function

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13
Q

PH of blood

A

7.35 / 7.45

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14
Q

PH of urine

A

6

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15
Q

Define buffer

A

Chemical substance that prevents too great a change in pH

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16
Q

What does the buffer do when the pH drops?

A

Binding with Hydrogen

17
Q

What does the buffer do when the pH rises?

A

Release hydrogen

18
Q

What does the buffers combine with that is excreted?

A

Combine with hydrogen ions to form compounds

19
Q

How is homeostasis maintained with a buffer?

A

Hydrogen ions are got rid of and pH of blood is regulated

20
Q

What is ammonia (NH3) synthesised by?

A

Epithelium cells of renal tubules

21
Q

What does the ammonia react with?

A

Excess hydrogen to form ammonium ion (NH4)

22
Q

What does the ammonia buffer regulate?

A

Acid-base balance