true/false Qs

Question 1

defects in NADPH oxidase activity in phagolytic cells causes primary immunodeficiency

Answer 1

T

Question 2

loss of Btk activity causesprimary immunodeficiency

Answer 2

T

Question 3

radiation therapy causes primary immunodeficiency

Answer 3

F (aqcuired)

Question 4

defects in C5-C9 of complent causes increased susceptibility to Staph. Aureus

Answer 4

T

Question 5

opsinisation of extracellular bacteria is affected by defects in C5-C9 of complemet

Answer 5

F

Question 6

complement defects lead to increased incidence of niesseria spp

Answer 6

T

Question 7

which stages of malaria infection cause immune response

Answer 7

sporozoites following mosquito injection
extracellular merozoites
parasites within hepatocytes

Question 8

natural resistance to malaria is provided by T cell memory

Answer 8

F

Question 9

natural resistance to malaria is provided by overexpression of G6P dehydrogenase

Answer 9

F

Question 10

primary immunodeficiencies are common

Answer 10

F

Question 11

primary immunodeficiencies are encoded by a recessive gene defect

Answer 11

T

Question 12

Treg cells and their prodction of IL-10 and TGFb can contribute to tumoour immuno-evasion

Answer 12

T

Question 13

IgA is mucosal

Answer 13

T

Question 14

IgG is mucosal

Answer 14

f

Question 15

conjugate vaccines can produce immune responses to non protein antigens

Answer 15

T

Question 16

vaccines do not need to contain antigens that are present in a pathogen to confer preotective immunity

Answer 16

F

Question 17

the sabin oral polio vaccine is an attenuated vaccine

Answer 17

T

Question 18

the salk polio vaccine is treated wit formaldehyde

Answer 18

T

Question 19

the salk polio vaccine is more effective than the sabin vaccine in stimulating mucosal immunity

Answer 19

F

Question 20

live attenuated vaccines can have inherent adjuvant properties

Answer 20

T

Question 21

Alum is aluminium hydroxyphosphate

Answer 21

T

Question 22

presence of Tumour infiltrating lymphocytes confer a good prospect of survival

Answer 22

T

Question 23

MAGE-1 and MAGE-2 are TAA frequently expressed in melanoma

Answer 23

T

Question 24

loss of B7.1 and b7.2 in cancer cells leads to increase CD8 recognition

Answer 24

F

Question 25

GM-CSF recruits DCs to cancers

Answer 25

T

Question 26

NKG20 is a receptor on NK cells involved in the recognition of cancer cells

Answer 26

T

Question 27

DCs are crucial targets for adjuvants

Answer 27

T

Question 28

antigen-adjuvant fusion decreases immunogenicity

Answer 28

F

Question 29

coleys toxins were first used against snake venom

Answer 29

F(cancer)

Question 30

TH1 response during fungal infections is likely to lead to clearance

Answer 30

T

Question 31

Th17 play no role in fungal infections

Answer 31

F

Question 32

fungal PAMPs incl mannans, glucans, mannosides

Answer 32

T

Question 33

recombinant GM-CSF inhibitors are often given to bone marrow donors

Answer 33

F

Question 34

IL-2 is used to expand T cells ex vivo

Answer 34

T

Question 35

engineered chimeric TCRs may recognise non peptide tumour antigens

Answer 35

T

Question 36

infliximab is an anti-TNFa monoclonal antibody

Answer 36

T

Question 37

herceptin targets angiogenesis in breast cancers

Answer 37

F (targets cell proliferation via Her2 receptors)

Question 38

chimeric antibodies have human fab fragments

Answer 38

F (mouse)

Question 39

humanised antibody therapy usually requires adjuvants

Answer 39

F