true/false Qs Flashcards
defects in NADPH oxidase activity in phagolytic cells causes primary immunodeficiency
T
loss of Btk activity causesprimary immunodeficiency
T
radiation therapy causes primary immunodeficiency
F (aqcuired)
defects in C5-C9 of complent causes increased susceptibility to Staph. Aureus
T
opsinisation of extracellular bacteria is affected by defects in C5-C9 of complemet
F
complement defects lead to increased incidence of niesseria spp
T
which stages of malaria infection cause immune response
sporozoites following mosquito injection
extracellular merozoites
parasites within hepatocytes
natural resistance to malaria is provided by T cell memory
F
natural resistance to malaria is provided by overexpression of G6P dehydrogenase
F
primary immunodeficiencies are common
F
primary immunodeficiencies are encoded by a recessive gene defect
T
Treg cells and their prodction of IL-10 and TGFb can contribute to tumoour immuno-evasion
T
IgA is mucosal
T
IgG is mucosal
f
conjugate vaccines can produce immune responses to non protein antigens
T
vaccines do not need to contain antigens that are present in a pathogen to confer preotective immunity
F
the sabin oral polio vaccine is an attenuated vaccine
T
the salk polio vaccine is treated wit formaldehyde
T
the salk polio vaccine is more effective than the sabin vaccine in stimulating mucosal immunity
F
live attenuated vaccines can have inherent adjuvant properties
T
Alum is aluminium hydroxyphosphate
T
presence of Tumour infiltrating lymphocytes confer a good prospect of survival
T
MAGE-1 and MAGE-2 are TAA frequently expressed in melanoma
T
loss of B7.1 and b7.2 in cancer cells leads to increase CD8 recognition
F
GM-CSF recruits DCs to cancers
T
NKG20 is a receptor on NK cells involved in the recognition of cancer cells
T
DCs are crucial targets for adjuvants
T
antigen-adjuvant fusion decreases immunogenicity
F
coleys toxins were first used against snake venom
F(cancer)
TH1 response during fungal infections is likely to lead to clearance
T
Th17 play no role in fungal infections
F
fungal PAMPs incl mannans, glucans, mannosides
T
recombinant GM-CSF inhibitors are often given to bone marrow donors
F
IL-2 is used to expand T cells ex vivo
T
engineered chimeric TCRs may recognise non peptide tumour antigens
T
infliximab is an anti-TNFa monoclonal antibody
T
herceptin targets angiogenesis in breast cancers
F (targets cell proliferation via Her2 receptors)
chimeric antibodies have human fab fragments
F (mouse)
humanised antibody therapy usually requires adjuvants
F
