Cancer Immunology Flashcards
1
Q
how do immune cells recognise tumours
A
either by tumour associated antigens or tumour rejection antigens
2
Q
which molecules are often completely lost from the cell surface on tumour cells
A
MHC calss 1
3
Q
how do tumours evade immune surveilance
A
no MHC, no adhesion molcules and no co stimulatory molecules
4
Q
define immune editing
A
defects in AP to avoid the immune system
5
Q
how do cancer cells render the immune system inactive
A
they secrete TGFb (transforming growth factor b) which induces cell death of immune cells and also secrete chemokines to recruit Treg cells to suprress TH cells
