Extracellular Immunity Flashcards
Name 5 examples of soluble mediators
Defensins, lactoferrin, complement, Collectins, antibodies
What are the main receptors involved in innate defences?
TLRs, lectins eg mannose receptor
How is th2 response involved in defence against extracellular pathogens?
Promotes class switching, activates B cells, releases il-5 to increase no of eosinophils at site of infection, releases il-9 to activate basophils
What is the result of IgE binding basophils
Histamine release
What sort of response does th17 promote and how?
Inflammatory response by recruiting neutrophils and releasing inflammatory cytokines
What are the main cytokines involved in th17 response
Il-6, il-23, TGFb
What sort of immunity is th17 related to
Anti fungal and antibacterial
How do group A streptococcus pathogens prevent being phagocytosed?
Their complex capsule
How do group A strep bind host cells?
Invasions and adhesins
What is the role of the surface M protein on group A strep
Inactivates C3b (complement)
What are the symptomatic results of group a strep infection?
Necrosis, rheumatic fever, glomerulonephritis, toxic shock
How is toxic shock caused
Super antigen non specifically activates T cells
How does ecoli become harmful?
Horizontal transfer of virulence factors
What causes some strains of helobactor pylori to be virulent?
Pathogenicity island containing a type 4 secretion system which injects cagA, disrupting signalling, cell junctions and the cytoskeleton
Name a common sugar found on the surface of fungus that skews the immune response to th17 upon binding to lectins on T cell surface
Dectin-1
