Triptans

Question 1

MOA of triptans

Answer 1

Stimulate 5HT1B/1D Receptors —-> reduce CGRP release —-> reduce dilation of meningeal vessels dilation —-> used in migrane

Question 2

Oral triptans having slow oral absorption

Answer 2

Frovatriptan
Naratriptan

Question 3

Oral triptans having fast oral absorption

Answer 3

Rizatriptan
Sumatriptan
Zolmitriptan
Eletriptan
Almotriptan

Question 4

Triptans used as nasal spray

Answer 4

Zolmitriptan
Sumatriptan

Question 5

Fastest acting triptan

Answer 5

S/c sumatriptan

Question 6

DOC for migrane in pregnancy

Answer 6

Paracetamol

Question 7

Safest triptan in pregnancy

Answer 7

Sumatriptan

Question 8

Prophylaxis of migrane

Answer 8

Flunarizone
•Can: Cyproheptadine, candesartan, clonidine
•P: Pizotifen,propranolol
•R: increase release of Gaba-Gabapentin
•E
•V: Valproate
•E
•N: Nortriptyline
•T: Topiramate
•Migrane: Methysergide

Question 9

Drug used used in treatment of migraine

Answer 9

•Triptans
•5HT1F(+) : Lasmiditan
•CGRPr(-) : Rimegepant
•Ergot alkaloids: ergotamine, Dihydroergotamine
•D2(-) : Chlorpromazine, metoclopramide
•NSAIDS: Paracetamol, Ketorolac
•Opoids: intranasal butorphanol, oral codeine

Question 10

5HT3(-) examples and uses

Answer 10

•D: dolansetron
•R: ramosetron
•O: ondansetron
•P: palonosetron
•G:. Granisetron
*Use: Antiemetic