Prostaglandins

Question 1

Main action of prostaglandin analogues

Answer 1

Maintain patency of ductus arteriosus

Question 2

PG blockers will cause

Answer 2

Closure of patent ductus arteriosus

Question 3

PGE1 Analogues and uses

Answer 3

•Misoprstol: NSAIDS induced peptic ulcer, Abortion, PPH
•Alprostadil: Erectile dysfunction

Question 4

Drugs used in treatment of Erectile Dysfunction

Answer 4

Pyar: Phentolamine
Bhi: Bremelanotide (HSDD)
Nahi: Naltrexone
Kar: Ketanserin
S: Sildenafil
A: Alprostadil
K
T: Trazadone
A: Alviptadil

Question 5

PGE2 Analogues and uses

Answer 5

•Dinoprostone
•Uses: Cervical ripening, PPH

Question 6

PGI2 Analogues and uses

Answer 6

B: Beraprost
E: Epoprosterenol
T: Treprostinil
I: iloprost
S: Selexipag
Uses: Pulmonary hypertension

Question 7

PGF2(alpha) analogues and uses

Answer 7

•Carboprost: PPH, Abortion
•Latanoprost/ bimatoprost:(eye drop) open angle glaucoma

Question 8

S/E of PGF2

Answer 8

Heterochromia iridis
Dry eyes/ sandy eyes
Macular edema
Hypertrichosis