TB Flashcards
1
Q
Short acting MDR TB regimen
A
4-6: bdq-cfz-E-eto-z-lfx-Hh
5: lfx-cfz-z-e
2
Q
Long acting MDR TB regimen
A
18-20 months: bdq(6)-lfx-lzd-cfz-cs
3
Q
Regimen for drug sensitive TB
A
2HRZE/4HRE
4
Q
MOA of rifampicin
A
RNA Polymerase inhibitor
5
Q
MOA of pyrizinamide
A
Blocks fatty acid synthesis
Blocks mycolic acid synthesis
6
Q
MOA of Ethambutol
A
Blocks arabinosyl transferase
Reduced synthesis of arabinogalactan which is an important component of bacterial cell wall
7
Q
Optic neuritis is the important side effect of which drug
A
Ethambutol
8
Q
DOC for prophylaxis of TB
A
Isoniazid
9
Q
MOR for isoniazid
A
Kat G gene mutation
Kas A gene mutation
INH A gene overexpression
10
Q
Most hepatotoxic drug
A
Pyrizinamide
11
Q
Ethionamide is contraindicated to be given with
A
Isoniazid and thioacetazone due to cross resistance
