Trinity tute

Question 1

Totipotent can form whole being if given the right support

Answer 1

.

Question 2

Whats the difference between differentiation and determination?

Answer 2

determined cell - commits down a path but doesn’t require characteristics yet. Could look similar to the tissue its going to become - but doesn’t mean it needs to look a certain way, just means it has the relevant expression for a specific path

differentiation involves morphological changes

Question 3

transdifferentiation? why do we get it?

Answer 3

Ability to go from one to another differentiated cell type

Can happen in physiological states (i.e the cervix) and/or diseased states (i.e barrett’s oesophagus cahnge from squamous epithelial to intestinal)

It is a protective reflex by the body

Question 4

Different stem cell therapies

Autologous is from your own body, allogentic is from another individual within the same species

If from a different species - xenogenic

Answer 4

Allogeneic cells will cause a immune response - can be good for detecting the cancer and destroying (they have a 20% risk of dying from graft vs. host disease)

Question 5

what is a stem cell?

Answer 5

capabilty to self-renew and differentiate

Question 6

There are neiches within the body where the stem cells exist - the progenitor cells (multipotent) do most of the

Answer 6

.

Question 7

What do stem cells look like?

Answer 7

primitive morphology.

High nucleo/cytoplasmic ratio - cell is mostly nucleus (cell is all purple)

Question 8

research on stem, cells, which one do we use?

Answer 8

100 ethics board - can use human stem cells