Lecture 34 - Social media, crowd source funding monoaminergic neurons. Flashcards
what are the ways of investigating the specific function of a brain nuclei or of sub-populations of neurons within a specific nuclei
‘
Lesion brain regions (traditional) -
take out a region and look at effects.
But can damage other fibres of passage
Cannulation
- reversible
- versatile
- rod into the brain in which molecules can be delivered
- difficult to assess ‘normal behaviour with chronic treatment
- don’t know how far the drug is going though…
Viral vectors
- region and cell type specific
- versatile
- affected cells easily identifiable
What is a modified virus?
modified virus
- ability to replicate is inhibited
- selected because of low immnogenicity (wo’t cause inflammation)
specifically packaged genetic material
wide range of applications
(gene therapy, reasesrch)
What can be put in a viral vector?
Genes -proteins aogist antioxidants promotors
What can be done with a viral vector?
Mapping
chronic receptor (agonist or antagonist)
modulation
gene silencing
functional modulation
parmacogenetics
- put in receptor that are only activated by designer drugs (DREADDs)
- can look at parameters of what happens when activated
Optogenetics
- very fast activation
- stimulated by LASER
- can see acute behavioural responses (anger)
What is scientific advocacy?
Australian acedemy of science - lobby groups
What is science communication?
visiting schools,community groups
blogs
podcasts/radio/TV
articles for the public
What is science activism?
Facebook, twitter
interactive - a conversation rather than a lecture
collaborative
Why bother with social media?
passionate about a scientific topic
understand the community views on a topic
What are some facts about medical research crowdfunding?
success rate of 50-60%
small amounts $5000 - 30 000
over 30 crowd-funding research projects
