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Drugs - Allman > Trimethoprim > Flashcards

Trimethoprim Flashcards

1
Q

Excretion

Trimethoprim

A

80% unchanged via glomerular filtration and tubular secretion

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2
Q

ADR

Trimethoprim

A

N/V/D

Caution in patients with folate deficiency

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3
Q

Who is likely to have folate deficiency?

A

Alcoholics
Pregnant women
Debilitated ptns
Malabsorptive syndromes

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4
Q

Spectrum of activity?

Trimethoprim

A

G + and -

PCP

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5
Q

What is Trimethoprim used for?

A

Acute Uncomplicated UTI
Recurrent UTI prophylaxis
Traveler’s diarrhea

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6
Q

Mechanism for Bactrim - Trimethoprim/Sulfamethoxazole

A

Bactericidal
synergistic
reduce rate of emergence of resistance

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7
Q

Drug interactions with SMZ/TMP

A

Warfarin - potentiate anticoagulant effects

Methotrexate - can get displaced due to sulfonamides from bindings sites and increase free methotrexate

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8
Q

SMZ/TMP indications

A

UTI
GI infections
RTI
STDs

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9
Q

MOA

Trimethoprim

A

prevents Tetrahydrofolic acid formation

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Drugs - Allman (16 decks)

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