Chloramphenicol

Question 1

MOA

Chloramphenicol

Answer 1

Reversibly binds to the larger 50S subunit of the 70S ribosome

Question 2

What must occur before chloramphenicol is active?

Answer 2

hydrolysis in the intestine

Question 3

Which form of administration has incomplete hydrolysis for chloramphenicol?

Answer 3

IV

Question 4

How is the distribution in CSF?

chloramphenicol

Answer 4

excellent - 30-50% without inflamed meninges

Question 5

Metabolism

chloramphenicol

Answer 5

Liver - glucuronidation

Question 6

Spectrum of activity

chloramphenicol

Answer 6

G+ and -
Aerobic and anaerobic org
rickettsia
chlamydia

Question 7

Adverse effects of chloramphenicol

Answer 7

Reversible bone marrow depression – anemia , leukopenia, thrombocytopenia

Idiosyncratic Aplastic anemia (irreversible)

Gray Baby syndrome

Question 8

Mechanism for Gray Baby syndrome

Answer 8

Inhibition of mitochondrial protein synthesis

Newborns lack effective glucuronic acid conjugation mechanism for degradation/detox of chloramphenicol in the urine

Question 9

What is the presentation of gray baby syndrom?

Answer 9

vomiting, flaccidity
HYPOthermia
respiratory collapse
Gray color

Question 10

Use for chloramphenicol

Answer 10

Bacterial meningitis (H. flu, strep pneumo, neisseria meningitis)
- pnc/cephalosporin allergic 

Rickettsial infections