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Drugs - Allman > Linezolid Tigecycline Dapto Telavancin > Flashcards

Linezolid Tigecycline Dapto Telavancin Flashcards

1
Q

Individually static but combinatorially cidal drugs

A

Quinupristin/Dalfopristin (Synercid)

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2
Q

The mechanism for quinupristin/dalfopristin

A

irreversible bind to the 50S bacterial ribosomal subunit

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3
Q

What does Quinupristin inhibit?

A

inhibits chain formation resulting in early termination

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4
Q

What does Dalfopristin inhibit?

A

inhibits peptide elongation by interfering with peptidyl transferase

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5
Q

What are quinupristin/dalfopristin effecting against?

A

MRSA, PCN-resistant Strep pneumo, VRE

not good against E. faecalis

Anaerobes, some G -

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6
Q

What is the route of administration for Quinupristin/Dalfopristin?

A

IV only - PICC or Central line

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7
Q

Mechanism of Linezolid (Zyvox)

A

binds 23S ribosomal RNA of 50S subunit

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8
Q

What is special about Linezolid

A

IV = PO (100% bioavailable)

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9
Q

What does Linezolid work against?

A

MRSA, VISA, VRE, PCN-resistant Strep pneumo

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10
Q

Adverse effects of Linezolid?

A

Thrombocytopenia, superinfection (yeast), mitochondrial toxicity

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11
Q

Drug-drug intrxn of Linezolid

A

watch for serotinin storm

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12
Q

Used topically for MRSA colonization eradication from Nares?

A

Mupirocin (Bactroban)

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13
Q

Colistin - cidal or static?
coverage?
when is it used?
ADR?

A

cidal
SPACE coverage
last ditch efforts - against Pan-resistant gram neg organisms, SPACE (Psudomonas, Acinetobacter), resistant PEK bugs
Nephro/Neurotoxicity

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14
Q

What is the only use of Fosfomycin?

A

UTIs

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15
Q

What pathogens/patients is Fosfomycin good for?

A

MDR pathogens - G+ and -, MRSA/VRE, ESBL org

Multiple Abx allergy patient

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16
Q

Dose and ADR for Fosfomycin

A

3g/dose, GI tolerance in nature

17
Q

What is important about Tigecycline (Tygacil)?

A

Bacteriostatic

Does NOT attain high serum concentrations (XX Bacteremia XX)

18
Q

Unique coverage of Tigecycline?

A

MRSA/VRE
G - : CRE
Acinetobacter - not Psudomonas
Anaerobes (GI infections)

19
Q

Uses for Tigecycline?

A

Complicated skin infections, intra-abdominal infections, Community acquired pneumonia (CAP)

20
Q

Why does Daptomycin not cover pneumonia?

A

Inactivated by pulmonary surfactant

21
Q

ADR for Daptomycin

A

Rhabdomyolysis

Eosinophilic pneumonia

22
Q

What is the semi-synthetic derivative of Vanc?

A

Telavancin

23
Q

What are ADRs associated with Telavancin?

A

Nephrotoxicity
Red man syndrome with infusion
QT prolongation
Pancreatitis

24
Q

What does Telavancin cover?

A

G+ orgs including MRSA

Drugs - Allman (16 decks)

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