Nitrofurantoin Flashcards
1
Q
Distribution
Nitrofurantoin
A
insignificant serum/tissue conc
high urine conc
2
Q
Excretion
Nitrofurantoin
A
rate is linear, related to CrCl
3
Q
How is excretion affected in patients with impaired GFR?
Nitrofurantoin
A
Decrease in efficacy
Increase in system toxicity
dont use if CrCl
4
Q
ADR
Nitrofurantoin
A
peripheral neuropathy
5
Q
What are the pulmonary reactions?
Nitrofurantoin
A
acute - hypersensitivity
subacute - after 1 month of therapy
chronic - after 6 months of therapy
may become irreversible
6
Q
Spectrum of activity
Nitrofurantoin
A
G + and G -
7
Q
Indications
Nitrofurantoin
A
Acute uncomplicated UTI treatment
UTI prophylaxis
