Trigger 1: extra

Question 1

glucagon inhibits

Answer 1

glycolysis

Question 2

how does glucagon inhibit glycolysis

Answer 2

by inhibiting glycogen synthase and promoting glycogen phosphorylase

Question 3

how does increased glucose concentration increase glycogen synthesis

Answer 3

when Akt is stimulated it stimulates enzymes which cause glycogenesis

Question 4

glucose conversion to glycogen

Answer 4

glucose is converted to glucose 6 phosphate by glucokinase

G6P converted to G1P

G1P converted to glycogen by glycogen synthase

Question 5

which enzyme promotes glycogenesis

Answer 5

glycogen synthase

Question 6

which enzyme stop glycogenesis

Answer 6

glycogen phosphorylase

Question 7

what other than glucose can stimulate glycolysis, which increases ATP, which increases closure of K+ and secretion of insulin

Answer 7

fatty acids, amid acids and GPR40

Question 8

fatty acids, amid acids and GPR40 stimulate

Answer 8

insulin secretion by stimulating kreb cycle (= increase in ATP and closure of k+)

Question 9

parasympathetic stimulation

Answer 9

increases insulin secretion by promoting Ach.

Ach promotes DAG which aids release of insulin

Question 10

sympathetic stimulation

Answer 10

Sym= inhibits cAMP, therefore decrease PKA, decreasing insulin release

Question 11

both GLU2 and glucokinase have

Answer 11

a low affinity for glucose

Question 12

glucokinase affinity for glucose

Answer 12

S0.5 8-10mM