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Antidepressants > Tricyclic Antidepressants (TCAs) > Flashcards

Tricyclic Antidepressants (TCAs) Flashcards

1
Q

Example

A

Amitriptyline

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2
Q

MoA

A

5-HT reuptake transporter, NA reuptake transporter
Inhibitor
Prevents reuptake of serotonin + NA
Increases duration of action at synapse

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3
Q

Indications

A

Depression

Pain at lower doses

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4
Q

ADR

A 
Fatal in OD
Sedation, Hangover 
Postural hypotension
Arrhythmias
Anticholinergic effects
Weight gain
Cardiac Anticholinergic
(Tachycardia, Urinary retention, Constipation, postural hypotension)
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5
Q

Prescribing Advice

A

X other antidepressants

Thrombocytopenia

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Antidepressants (5 decks)

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