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Antidepressants > Monoamine oxidase Inhibitors (MAOIs) > Flashcards

Monoamine oxidase Inhibitors (MAOIs) Flashcards

1
Q

Examples

A

Moclobemide

Phenylzine

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2
Q

MoA

A

Monoamine oxidase enzyme in synaptic cleft
Inhibitor
Prevents degradation of monoamine NTs = Serotonin
Increases duration of action at synapse

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3
Q

Indications

A

Treatment resistant Depression

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4
Q

ADR

A

Drowsiness
Anticholinergic effects
Weight gain
Hepatotoxicity

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5
Q

Prescribing Advice

A

RESTRICTIVE DIET
Reaction with tyramine containing foods:
- Cheese, Red wine; more likely in irreversible inhibitors
X other antidepressants

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Antidepressants (5 decks)

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