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MDT > Treponema pallidum > Flashcards

Treponema pallidum Flashcards

1
Q

What are the two broad categories of serologic tests for Syphilis?

A

Non-treponemal and Treponemal

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2
Q

Which of the two types of serologic tests for syphilis test for a cardiolipin-cholesterol-lecithin antigen?

A

Non-treponemal

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3
Q

What percentage of non-treponemal test may have a false negative when they first present with chancre?

A

20-30%

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4
Q

What are the non-treponemal tests?

A

Rapid Plasma Reagin (RPR) Venereal Disease Research Laboratory (VDRL) Toluidine Red Unheated Serum Test (TRUST)

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5
Q

What are the Treponemal serologic tests?

A

Fluorescent Treponemal antibody absorption (FTA-ABS) Microhemagglutination test for antibodies to T. pallidum (MHA-TP) T. pallidum particle agglutination assay (TPPA) T. pallidum enzyme immunoassay (TP-EIA) Chemiluminescene immunoassay (CIA)

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6
Q

Which Treponemal test has become the favored test in laboratories with large numbers of specimens to test?

A

T. pallidum enzyme immunoassay (TP-EIA)

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7
Q

Can the spirochete Treponema pallidum be cultured?

A

no

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8
Q

When are people with venereal syphilis most infectious?

A

during primary and secondary stages of the disease, when moist, mucocutaneous lesions are present *persons with early syphilis may also be infectious

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9
Q

What are the three subdivisions of tertiary syphilis?

A

neurosyphilis cardiovascular syphilis gummatous syphilis

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10
Q

what are some differential diagnosis of primary syphilis?

A

chancroid lymphogranuloma vernereum granuloma inguinale codylomata acuminata herpes simplex carcinoma

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11
Q

What are some differential diagnosis of secondary syphilis?

A

pityriasis rosea drug eruption psoriasis lichen planus viral exanthema Stevens-Johnson syndrome

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12
Q

What is the first line treatment of syphilis?

A

Penicillin G benzathine 2.4 million units IM x 1 dose

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13
Q

What is the treatment for syphilis in patients allergic to PCN?

A

Doxycycline 100mg BID x 2 weeks

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14
Q

What is the median incubation period before chancre appears in primary syphilis?

A

21 days (range 3-90 days)

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15
Q

How long will the chancre of primary syphilis typically take to heal without treatment?

A

six weeks

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16
Q

After the a syphilis chancre heals, what percentage of patients will experience the systemic illness that represents secondary syphilis?

A

25%

17
Q

What are the classic characteristics of the rash of secondary syphilis?

A

diffuse symmetric macular or papular eruption involving the entire trunk and extremities including the palms and soles

18
Q

What term describes the large raised, gray to white lesions that may develop in warm, moist areas such as the mouth and perineum of patients with secondary syphilis?

A

condyloma lata

19
Q

picture of secondary syphilis rash on palms

A
20
Q

picture of secondary syphilis on trunk

A
21
Q

picture of condyloma lata

A

MDT (8 decks)

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