Treatments with things in common

Question 1

Treatments for Brain Cancer

Answer 1

Carmustine (BCNU)
Cyclophasphamide (cytoxan)- neuroblastoma
Darcarbazine (DTIC)- neuroblastoma
Melphalan (Alkeran)- neuroblastoma
Temozolomide (Temodar)- astrocytoma and glioblastoma
Vincristine (oncovin)
Bevacizumab (Avastin)- glioblastoma
Thalidomide (Thalomid)- glioblastoma multiforme

Question 2

Causes Tumor Lysis Syndrome

Answer 2

Bendamustine (Treanda)

Rituximab (Rituxan)

Question 3

Causes Renal Toxicity

Answer 3

Carboplatin, Cisplatin (platinum chemos)
Carmustine (BCNU)
Thiotepa (thioplex)
Azacitidine (Vidaza)
Methotrexate (MTX)
Thioguanine (6-TG)
Bleomycin (blenoxane)
Mitomycin- C (mutamycin)

Question 4

Causes Pulmonary Toxicity

Answer 4

Carmustine (BCNU)
Chlorambucil (Leukeran)
Capecitabine (Xeloda)
Gemcitabine (Gemzar)
Mitomycin- C (mutamycin)
Teniposide (Vumon, VM-26)
Cetuximab (Erbitux)

Question 5

Causes Bladder Toxicity

Answer 5

Cyclophosphamide (Cytoxan)

Ifosfamide (Ifex)- hemorrhagic cystitis, dysuria

Question 6

Causes Cardiotoxicity

Answer 6

Cyclophosphamide (cytoxan)
Anthracyclines (daunorubicin, doxorubicin, doxorubicin, epirubicin, idarubicin)
Fluoruourcil (5-FU)
Trastuzumab (Herceptin)

Question 7

Causes Hepatic Toxicity

Answer 7

Busulfan (Myleran)
Carmustine (BCNU)
Oxaliplatin (Eloxatin)
Mercaptopurine (6-MP)
Thioguanine (6-TG)
Methotrexate (MTX)

Question 8

Causes Neurotoxicity

Answer 8

Darcarbazine (DTIC)- CNS tox
Ifosfamide (Ifex)
Oxaliplatin (Eloxatin)
Fludarabine (fludara)

Question 9

Causes Hand Foot Syndrome

Answer 9

Fluorouracil (5-FU)
Capecitabine (Xeloda)
Doxorubicin (Adriamycin)
Doxorubicin Liposomal (Doxil)
Idarubicin (idamycin)

Question 10

Causes Hypokalemia

Answer 10

Cisplatin (platinol)
Azacitidine (Vidaza)
Nivolumab (Opdivo)

Question 11

Causes SIADH/ Hyponatremia

Answer 11

Chemos where peeing is important :
Cisplatin (Platinol)
Cyclophosphamide (SIADH)
Ifosfamide (Ifex)

Vincristine (Oncovin)
Nivolumab (Opdivo)
Pembrolizumab (Keytruda)

Question 12

Causes Hypomagnesemia

Answer 12

Cisplatin (Platinol)
Cetuximab (Erbitux)
Panitumumab (vectibix)
Nivolumab (opdivo)

Question 13

Causes skin/ nail changes

Answer 13

Thiotepa (Thioplex)- bronzing of skin
Hydroxyurea (Hydrea)- darkening or thickening of nails
Bleomycin (blenoxane)- hyperpigmentation, skin and nail changes
anthracycline antitumor antibiotics- daunorubicin, doxorubicin, doxorubicin liposomal
Etoposide (Vepesid)- yellowing of the skin/ eyes
Docetaxel (taxotere)

Question 14

Causes photosensitivity

Answer 14

Temozolomide (Temodar)- brain cancers
Fluorouracil (5-FU)
Methotrexate (MTX)

Question 15

Causes Myalgia/ Arthralgias

Answer 15

Paclitaxel (Taxol)
Paclitaxel Protein Bound (Abraxane)
SERMS
Aromatase inhibitors

Question 16

Causes peripheral neuropathy

Answer 16

Carboplatin (Paraplatin)
Cisplatin (Platinol)
Oxaliplatin (Eloxatin)

Taxanes (Paclitaxel, Docetaxel, Paclitaxel protein bound)

Vincristine (Oncovin)
Ado-tratuzumab emantine (Kadcyla)

Question 17

Causes rash/ pruritus

Answer 17

Chlorambucil (Leukeran)- rash
Fludarabine (fludara)- rash
Gemcitabine (Gemzar)- rash
Pemtrexed (Alimta)- rash
THioguanine (6-TG)- rash
Epirubicin (Ellence)- rash

Pertuzumab (Campath)- rash
Cetuximab (Erbitux)
Panitumumab (vectibix)

PD-1/ PD-L1 monoclonal antibodies (ipilimumab, nivolumab, pembro)
Ubiquitin E3 Ligase cereblon (revlimide/ thalomide)- rash
SERMs