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GI II > Treatments for GI Infection > Flashcards

Treatments for GI Infection Flashcards

1
Q

Abx of choice for C. difficile

A

vancomycin, fidaxomicin

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2
Q

Abx of choice for C. jejuni, Salmonella, Shigella

A

Cipro and azithromycin

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3
Q

MOA benzimidazoles

A

inhibition of microtubule polymerization via beta-tubulin binding and inhibition of mitochondrial fumarate reductase

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4
Q

MOA Ivermectin

A

binds selectively to glutamate-gated ion channels, induces hyperpolarization and results in tonic paralysis

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5
Q

MOA nitazoxanide

A

interferes with pyruvate:ferredoxin oxioreductase enzyme-dependent electron transfer reaction

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6
Q

MOA praziquantel

A

increases cell membrane permeability resulting in loss of intracellular calcium

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7
Q

MOA pyrantel pamoate

A

depolarizing neuromuscular blocker, opens cation channels and induces activation of nAChr, inhibits cholinesterases and results in spastic paralysis

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8
Q

MOA paromomycin

A

works similarly to aminoglycosides, on 30-S protein

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9
Q

MOA metronidazole and tinidazole

A

activated by electron transfer process creating nitro-radicals which disrupts DNA

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10
Q

MOA Atovaquone

A

interferes with mitochondrial electron transport and ATP/pyrimidine biosynthesis

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11
Q

MOA proguanil

A

inhibits DHF reductase-TMS enzyme, decreasing inhibition of DNA synthesis

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12
Q

Agent of choice for entamoeba histolytica

A

metronidazole followed by paromomycin

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13
Q

Agent of choice for ancylostoma and Necator

A

albendazole

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14
Q

Agent of choice for ascaris lumbricoides

A

albendazole

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15
Q

Agent of choice for Giardia

A

metronidazole

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16
Q

Agent of choice for Diphyllobothrium latum and Taenia spp.

A

Praziquantel

17
Q

Agent of choice for Echinococcus granulosus

A

albendazole and praziquantel

18
Q

Agent of choice for Taenia solium

A

albendazole

19
Q

Agent of choice for Enterobius vermicularis

A

mebendazole

20
Q

Agent of choice for shistosoma

A

Praziquantel

21
Q

Agent of choice for strongyloides

A

Ivermectin

22
Q

Agent of choice for Trichuris trichuria

A

mebendazole

23
Q

Agent of choice for Trichinella

A

albendazole

24
Q

Agent of choice for cryptosporidium

A

nitazoxanide

25
Q

Agent of Cyclospora cayetanensis

A

TMP-SMZ, cipro for sulfa allergic

GI II (8 decks)

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