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GI II > IBD Treatments > Flashcards

IBD Treatments Flashcards

1
Q

Five drug classes for ulcerative colitis

A

5-ASA, JAK Inhibitors, TNFa inhibitors, IL-12/23 inhibitors, a-4 integrin inhibitors

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2
Q

Three drug classes for Crohn Disease

A

IL-12/23 inhibitors, TNF-a, a-4 integrin inhibitors

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3
Q

MOA 5-ASA agents

A

inhibit prostaglandin and leukotriene production via arachodonic acid pathway, block COX and LIPOX; reduce PMN and macrophage chemotaxis

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4
Q

5-ASA agents

A

sulfasalazine, mesalamine, olsalazine, balsalazine

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5
Q

5-ASA side effects

A

CNS and GI related

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6
Q

Contraindications for 5-ASA compounds

A

ASA allergy, sulfonamide allergy

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7
Q

Indications for 5-ASA

A

Mild-to-moderate UC; olsalazine is only for maintenance, balsalazide only for active disease

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8
Q

TNF-a inhibitor MOA

A

bind and inhibit TNF-a to decrease leukocyte migration (VCAM and E-selectin not upregulated

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9
Q

TNF-a inhibitor administered by IV

A

Infliximab

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10
Q

TNF-a inhibitor side effects

A

infections, liver toxicity, EM, SJS, TEN, malignancies

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11
Q

Indications for adalimumab

A

moderate to severe UC and CD

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12
Q

Indications for infliximab

A

CD and UC

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13
Q

Indications for certolizumab

A

moderate-to-severe CD only

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14
Q

Indications for golimumab

A

moderate-to-severe UC only

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15
Q

a-integrin action

A

adhesion molecules, bind to E-selectin and VCAM, leukocyte adhesion

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16
Q

a-integrin inhibitor MOA

A

limit integrin-associated cell adhesion, natalizumab binds both a4B1 and a4B7, vedolizumab binds only a4B7

17
Q

a-integrin inhibitor drugs

A

natalizumab and vedolizumab

18
Q

Side effects a-integrin inhibitiors

A

infections, especially PML(black box warning)

19
Q

Natalizumab indications

A

active and maintenance of moderate-to-severe CD

20
Q

Vedolizumab indications

A

active and management of moderate-to-severe CD and UC

21
Q

IL-12/23 inhibitors MOA

A

bind to P40-subunit of IL-12 and 23 blocking activation of naive T cells and NK cells

22
Q

IL inhibitor drug

A

Ustekinumab

23
Q

IL inhibitor side effects

A

infections (TB)

24
Q

IL inhibitor indications

A

moderate-to-severe UC and CD, for patients

25
Q

JAK inhibitor MOA

A

Bind and inhibit jak-1 and jak-3, inhibiting gene transcription and cytokine release

26
Q

JAK inhibitor drug for IBD

A

tofacitinab (PO)

27
Q

Side effects JAK inhibitor

A

lymphopenia, neutropenia, anemia, increase LDL and HDL

28
Q

Indications for JAK inhibitor

A

active and management of moderate-to-severe UC

29
Q

Indications for steroids for IBD

A

acute and/or severe UC and CD uncontrolled by other meds; use lowest dose for shortest duration possible

GI II (8 decks)

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