treatment of PD Flashcards
discuss levodopa as treatment
Carbidopa-levodopa combination - taken up by dopamine terminals in striatum - converted do DA by dopa decarboxylase - released and acts at DA receptors
discuss anticholinergics as treatment
benadryl (good for treating tremors and dystonia) - block muscarinic cholinergic receptors - lessens hyperactivity - restores function
discuss amantadine as treatment
improves bradykinesia and tremor - dec DA reuptake
used as monotherapy or conjunction c levodopa
discuss selegeline as treatment
MAO-B INHIBITOR - reduces DA metabolism = reduces oxidative stress and free radicals
discuss COMT inhibitor as treatment
reduces dopamine breakdown
discuss tolcapone as treatment
adjunct therapy to carbidopa/levodopa therapy
inhibits COMT
but not used anymore bcs can lead to cancer
effects and precautions of levodopa
immed response
long term use leads to dyskinesia kaya need of rest periods
may induce oxidative stress
nausea, hallucinations and orthostasis
discuss surgical treatment
deep brain stimulation - most effective
pallidotomy - improves contralateral dyskinesia
