Treatment of non-HDL & HDL Flashcards
What are Fibric Acid Derivatives (Fenofibrates) indicated for?
Treatment of non-HDL & HDL
Which Fenofibrates have higher bioavailibitly? (2)
Antara
Lofbira
Which Fenobibrates can be taken without regard to food? (3)
Fenoglide, Lofibria, Lipofen
How can fenofibrates affect kidney function? (2)
Can increase CrCl by >2
No change seen in GFR
When is renal dosing necessary for fenofibrates and what is that dosing?
CrCl <30-80
AVOID if >30
When should use of fenofibrates be avoided? (5)
Whenever CrCl less than 30 Hx of DVT Hx of PE Active gallstones Hyperhomocysteinemia
What statin dosing practice can be initiated to help decrease risk of drug interactions?
Once-daily dosing
How is Gembibrozil dosed?
Twice daily on an empty stomach (can cause GI issues)
When should Gembibrozil be avoided? (2)
Active gallstones
Hyperhomocysteinemia
What increases the risk of myositis and rhabdo in Gembibrozil use?
Use with statins
Gemfibrozil drug reactions? (2)
Warfarin (increases fibrinogen by 20%)
Statins (especially Simvastatin)
What drugs fall under Fibric Acid Derivatives for the treatment of non-HDL & HDL? (3)
Fenofibrates
Gemfibrozil
Omega-3 Fatty Acids
What 3 Omega-3 Fatty Acids are used to treat non-HDL and HDL?
Lovaza
Omtryg
Vascepa
What is the typical dosing for Lovaza for treatment of non-HDL & HDL?
1mg
What is the typical dosing range for Omtryg
1.2mg-4g/day single or divided doses
What are the causes of low-HDL? (8)
Elevated TG Overweight Inactivity Smoking Very high carb intake ( >60% of energy) BB Anabolic steroids Pregestational agents
What affect can 4g of Lovaza/Omtryg have on TG?
Decrease of up to 30%
How should Lovaza and Omtryg be taken in relation to food?
Take without food
What Omega-3 Fatty Acid is used for TG of 500-2000?
Vascepa
What is the dosing for Vascepa for the treatment of TG?
2 caps (2g) BID
How should Vascepa be taken in relation to food?
Take with food
