treatment of anemia

Question 1

treatment for iron deficiency anemia: rapid increase in reticulocytes within 1 week , 3-6 month therapy, includes sulfate/gluconate/fumarate

Answer 1

oral ferrous salts

Question 2

iron toxicity (children, GI irritation, shock, metabolic acidosis) treated with the iron chelator _______

Answer 2

deferoxamine

Question 3

treatment for iron deficiency anemia when oral iron intolerance, GI surgery, or IBD of duodenum

Answer 3

iron dextran

Question 4

major side effect of iron dextran?

Answer 4

hypersensitivity reaction

Question 5

chronic toxicity due to long term transfusions, depositis in heart/liver/pancreas, leads to organ failure, treated with phlebotomy in absence of anemia

Answer 5

hemochromatosis

Question 6

______ absorbed in proximal jejunum by active transport, ______ absorbed in ileum through intrinsic factor made by gastric parietal cells

Answer 6

folic acid

vitamin B12

Question 7

parenteral treatment for B12 deficiency, long term

Answer 7

cyanocobalamin

Question 8

protein bound treatment for B12 deficiency, longer hald life but risk of antibody response

Answer 8

hydroxycobalamin

Question 9

-stimulates RBC production, used for anemia with chronic renal failure and chemo

Answer 9

EPO (epoietin alpha)

Question 10

recombinant granulocytic macrophage colony stimulating factor, adverse events common (fever, malaise, arthralgia, capillary leak syndrome)

Answer 10

sargramostim (GM-CSF)

Question 11

• recombinant colony stimulating factor
• prevents/treats cytotoxic chemo related neutropenia, reduces time to engraftment after autologous SCT
• treats inherited disorders of myeloid production
• temporary bone pain

Answer 11

filgrastim G-CSF)

Question 12

• promotes megakaryopoiesis
• increases peripheral platelets, decreases need for platelet transfusions
• adverse: fatigue, dizziness, anemia, dyspnea

Answer 12

oprelvekin (IL-11)

Question 13

treatment for folic acid deficiency?

Answer 13

folic acid, leucovorin