Immunotherapy

Question 1

naturally occurring proteins, inhibit oncogenes and act on tumor cells/NK/T/macrophages
-used to treat hairy cell leukemia and mycosis fungoides

Answer 1

interferons

Question 2

cytokines secreted by white cells, enhance tumor ID and kill

-used to treat renal cell carcinoma (IL-2), graft vs host disease

Answer 2

interleukins

Question 3

targets CD20 on B cells, lysis or apoptosis, used in most B cell lymphomas or any disease with aberrant CD20 expressing B cells, vitamin R
-high reactivation of HBV and PML

Answer 3

rituximab

Question 4

anti CD52, targets B and T cells, treats CLL refractory to alkylating agents, high viral reactivation

Answer 4

alemtuzumab

Question 5

inhibition via B7 receptor on T cells, activates inhibitory pathway, increased immune response

Answer 5

CTLA4, ipilimumab

Question 6

bispecific antibody, engages T cell and tumor cells to get the T cell to kill the tumor cell

Answer 6

BiTE

Question 7

antibody with a radiolabeled isotope binds to tumor cells and also kills adjacent cells, in vitro radiotherapy

Answer 7

radiolabeled mab

Question 8

conjugated with chemo drug, specific for CD30 (Hodgkins)

Answer 8

brentuximab

Question 9

tumor specific antigen to produce specific antibody, great for low grade lymphomas

Answer 9

active vaccination

Question 10

gives T cell “eyes” to see the tumor cell without MHC/HLA, chimeric antigen receptor put on the T cell

Answer 10

CART