Transporting Carbon Dioxide Flashcards

1
Q

Carbon dioxide is released from respiring tissues and it must be removed from tissues to the lungs.
What are the three ways carbon dioxide is transported

A

10% is combined with haemoglobin to make carbaminohaemoglobin
85% is transported in form of hydrogen carbonate
5% is dissolved directly into the plasma

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2
Q

When carbon dioxide diffuses into an erythrocyte from blood plasma, it reacts with water to form …..

A

Carbonic acid.
H2CO3

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3
Q

what enzyme catalyses the formation of carbonic acid

A

Carbonic anhydrase

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4
Q

what two things does carbonic acid dissociate into

A

Hydrogen ions H+
Hydrogen carbonate HCO3-

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5
Q

What is the chloride shift?

A

When hydrogen carbonate ions HCO3- diffuse out of the erythrocyte into the plasma through a membrane bounds transport protein

Cl- diffuse into the erythrocyte through the same membrane bound transport protein to balance the electrical charge inside the blood cell

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6
Q

How does haemoglobin turning to haemoglobinic acid act as a buffer in the erythrocyte

A

Because if there are too many hydrogen ions in the blood cell, it can cause the erythrocyte to become acidic/ lower the ph

Therefore, hydrogen ions are taking out of the solution by associating with haemoglobin and forming Haemoglobinic acid.
Therefore its maintaining a constant ph.

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7
Q

What is the Bohr shift?

A

On the haemoglobin disociation curve, the bohr shift shows the curve shifting downwards and to the right due to carbon dioxide levels

This is showing haemoglobin has a lower affinity for oxygen, causing it to disociate, resulting in a higher partial pressure of oxygen.

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8
Q

Too many Hydrogen ions can make the erythrocytes cytoplasm more….

A

Acidic

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9
Q

which curve shows the bohr effect, the left or right

A

right

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10
Q

what is the bohr effect

A

when lots of co2 is present, usually around working muscles, more carbonic acid is formed, which dissociates into H+ and Hydrogencarbonate

Lots of H+ alters the tertiary structure of haemoglobin, reducing the oxygen affinity. Therefore more oxygen is being released into the plasma.

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11
Q

what is the symbol for hydrogencarbonate

A

HCO3-

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12
Q

what is the symbol for carbonic acid

A

H2CO3-

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13
Q

what is haemoglobinic acid written as

A

HHb

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14
Q

is chloride an anion or a cation

A

anion CL-

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15
Q

how is haemoglobinic acid formed

A

by haemoglobin binding with hydrogen ions to prevent the erythrocyte becoming acidic

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