Transporting Carbon Dioxide Flashcards
Carbon dioxide is released from respiring tissues and it must be removed from tissues to the lungs.
What are the three ways carbon dioxide is transported
10% is combined with haemoglobin to make carbaminohaemoglobin
85% is transported in form of hydrogen carbonate
5% is dissolved directly into the plasma
When carbon dioxide diffuses into an erythrocyte from blood plasma, it reacts with water to form …..
Carbonic acid.
H2CO3
what enzyme catalyses the formation of carbonic acid
Carbonic anhydrase
what two things does carbonic acid dissociate into
Hydrogen ions H+
Hydrogen carbonate HCO3-
What is the chloride shift?
When hydrogen carbonate ions HCO3- diffuse out of the erythrocyte into the plasma through a membrane bounds transport protein
Cl- diffuse into the erythrocyte through the same membrane bound transport protein to balance the electrical charge inside the blood cell
How does haemoglobin turning to haemoglobinic acid act as a buffer in the erythrocyte
Because if there are too many hydrogen ions in the blood cell, it can cause the erythrocyte to become acidic/ lower the ph
Therefore, hydrogen ions are taking out of the solution by associating with haemoglobin and forming Haemoglobinic acid.
Therefore its maintaining a constant ph.
What is the Bohr shift?
On the haemoglobin disociation curve, the bohr shift shows the curve shifting downwards and to the right due to carbon dioxide levels
This is showing haemoglobin has a lower affinity for oxygen, causing it to disociate, resulting in a higher partial pressure of oxygen.
Too many Hydrogen ions can make the erythrocytes cytoplasm more….
Acidic
which curve shows the bohr effect, the left or right
right
what is the bohr effect
when lots of co2 is present, usually around working muscles, more carbonic acid is formed, which dissociates into H+ and Hydrogencarbonate
Lots of H+ alters the tertiary structure of haemoglobin, reducing the oxygen affinity. Therefore more oxygen is being released into the plasma.
what is the symbol for hydrogencarbonate
HCO3-
what is the symbol for carbonic acid
H2CO3-
what is haemoglobinic acid written as
HHb
is chloride an anion or a cation
anion CL-
how is haemoglobinic acid formed
by haemoglobin binding with hydrogen ions to prevent the erythrocyte becoming acidic