Transport Along and Across the GI Tract Flashcards
How does gastric accommodation occur?
→ Decrease in cholinergic activity
→ VIP / NO promote accommodation
Where do tonic contractions start from?
→ The top of the antrum
What does the stomach do to store food and why?
→ The proximal stomach relaxes to store food at low pressure while it is acted on by acid and enzymes mechanically
Why is gastric emptying carefully regulated?
→ It ensures adequate acidification/neutralization
→ Action of enzymes, mechanical breakdown
→ avoid swamping the duodenum
What is a disorder of gastric emptying?
→ Gastric stasis
gastroparesis
What is gastric emptying dependent on?
→ Propulsive force generated by the tonic contractions of the proximal stomach
→ The stomachs ability to differentiate types of meals ingested and their components
What decreases the force and rate of gastric emptying?
→ Fatty, hypertonic and acidic chyme in the duodenum
How do liquids pass?
→ in spurts
How do solids pass?
→ Broken down into 1-2mm sizes
How do large indigestible materials pass?
→ Cleared by migrating motor complex
→ or vomiting
How are liquids emptied?
→ Rapidly disperse
→ Empty without a lag time
What is the rate of liquid emptying dependent on?
→ The rate of emptying is influenced by nutrient content
→ Nutrient rich liquids are retained for longer
How many phases are there in solid emptying?
→ 2 phases ( lag time and linear phase)
What is the duration of the lag time related to in solid emptying?
→ Duration of the lag time is related to the size of the particle
How are solids emptied?
→ Trituration of larger particles to smaller ones
→ Pylorus regulated the passage of material
→ (60 mins for a typical solid-liquid meal)
What is the order of highest gastric motility to lowest?
→ carbohydrates > proteins > fatty foods > indigestible solids
Liquefy at body temperature; float on top of liquid layer and empty slowly
What are the determinants of gastric motility?
→ Types of food eaten
→ Osmotic pressure of duodenal contents
→ Vagal innervation upon over distension
→Hormones
What hormones inhibit emptying?
→ Somatostatin
→ CCK
→ Secretin
→ GIP
What does injury to the intestinal wall and bacterial infections cause?
→ Decrease in motility
How does the osmotic pressure of duodenal contents affect gastric motility?
→ Hyperosmolar chyme decreases gastric emptying
What is BER?
→ Intrinsic basic electrical rhythm
What does BER allow?
→ smooth muscle cell to depolarize and contract rhythmically when exposed to hormonal signals
What do the stomach cells produce from resting potential?
→ Electrical depolarizations
→ Move ripples towards the antrum
What control is the fundus under?
→ Vagal excitatory control
What is an ICC?
→ Cajal cells
→ Pacemaker cells in the wall of the stomach, small intestine and large intestine
What produces the BER?
→ Regular migrating ripples from the ICC
reduced by sympathetic innervation- NA
What are the depolarizations due to?
→ Entry of K+ and Ca2+
What mediates a decrease in fundic motor activity?
→ Cholecystokinin → Secretin → VIP → Somatostatin →Duodenal distension → Gastrin releasing peptide
What increases fundic contractions?
→ Motilin
What initiates and maintains peristalsis in the small intestine?
→ Hormonal and nervous factors
What decreases activity in the small intestines?
→ Secretin
What does antral over distension cause?
→ Inhibitory signals
→ Vago- vagal reflex
What does distension of the fundus cause?
→ Excitatory effects in the antrum
→ Antrum contracts
What happens during duodenal over distension and chemical stimulation?
→ Vago-vagal reflex and hormones
What does the pyloric sphincter contract in response to?
→ Antral or duodenal rhythms
What do fatty acids in the duodenum cause?
→ Contraction of the pylorus
What promotes the relaxation of the pyloric sphincter when the duodenum has no food in it?
→ NO and VIP
What causes the pylorus to relax?
→ Descending inhibitory reflex
What are the types of movements in the intestine?
→ Segmentation (mixing contractions)
→ Peristalsis propulsive): in stomach (3 waves/min)
→ Migrating Motor Complex
→ Mass movements