Regulation And Disorders Of Gastric Secretion Flashcards
What are the contents of gastric juice (fasting)?
→ Cations : Na+, K+, Mg2+, H+ →Anions : Cl-, HPO42+, SO42- →Pepsinogen →Lipase →Mucus →Intrinsic factor
How much does gastric juice add (volume) to intestinal contents?
→ 2.5L
What do the fundus and body secrete?
→ Mucus
→HCl
→Pepsinogen
What does the antrum secrete?
→less HCl secretion but more gastrin secretion
What kind of cells does the body of the stomach have?
→ numerous epithelial cells with numerous tubular glands
What are the walls of the tubular glands lined with?
→ Parietal cells
→ HCl and intrinsic factor
What does the pylorus provide for the chyme?
→ An exit route for the chyme to pass through into the duodenum
What are the exocrine secretions of the stomach?
→mucus
→acid,
→pepsinogen
Why don’t you want histamine to be exocrine?
→ It has wide ranging effects in the body
What do ECL cells secrete?
→ Paracrine agents such as histamine
How is gastric acid made in the stomach?
→CO2 diffuses into the cell
→It forms carbonic acid via carbonic anhydrase
→Carbonic acid dissociates into bicarbonate and H+
→HCO3- is transported out and Cl- is transported in to maintain charge- chloride shift
→The H+ can form water and flux into the lumen
→It can be exchanged for K+ by an ATPase
→H+ and Cl- form HCl in the lumen
→Accumulation of osmotically-active hydrogen ion in the cannaliculus generates outward diffusion of water - the resulting gastric juice is 155 mM HCl and 15 mM KCl with a small amount of NaCl.
What is the pH of gastric juice?
→ pH 7.4 -7.7
What are the properties of mucus and what does it form?
→ thick
→ sticky
→ forms water insoluble gel on epithelial surface
What does mucus do?
→ Protects against H+
What does rennin do?
→ Curdles milk into casein clot
→also known as chymosin
→ synthesised by chief cells
What does lipase break down and what are the products?
→ triglycerides
→ into fatty acids and glycerol
What happens if you don’t release lipase?
→ Steatorrhea
fatty stool
What is intrinsic factor for?
→ Absorption of B12
What converts pepsinogen to pepsin?
→ High acidity
What do parietal cells secrete?
→ Acid
What is the role of gastric acid?
→Kills bacteria; acid denaturation of digested food; creates the optimum pH for the activation of pepsinogen to pepsin for protein digestion
→Promotes the action of gastric lipase; and the secretion of pancreatic HCO3-
What do non parietal cells secrete?
→ Juice similar to plasma
→resting juice = plasma; but alkaline, pH7.4; ↑HCO3-
When does HCl secretion increase?
→ HCl secretion increases
What are the three phases of secretion?
→Cephalic phase
→Gastric phase
→Intestinal Phase
What is HCl secretion regulated by?
→neuronal pathways and duodenal hormones
What is the direct pathway?
→act on parietal cells and increase acid secretion
What is the indirect pathway?
→ Influence the secretion of gastrin and histamine increases acid secretion
What kind of a secretion is gastrin?
→ A hormonal secretion
What starts the cephalic phase?
→ Sight
→ Smell
→ taste
→ chewing
What happens during the cephalic phase?
→there is ACh release
→Increases the parasympathetic preganglionic neuron activity.
→This stimulates the enteric neurons
→ACh binds to receptors on the parietal cells and stimulates them
→Stimulates release of gastrin from G cells
→Gastrin binds to ECL cells
→ECL cells secrete histamine
→This causes secretion
ACh stimulates histamine release from ECL cells
ACh acts directly on parietal cells → HCl secretion
What happens if there is hypersecretion of acid?
→D cells are stimulated
→secrete somatostatin which has inhibitory effects on ECL cells and parietal cells binds to SS-R receptor on parietal
→Acid secretion is reduced.
What happens in the gastric phase?
→Distention of the stomach occurs
→Increased peptide concentration and increased acidity
→When the food has peptides in it the food acts as a buffer
→They will stop HCL stimulating D cells
→The inhibition of acid secretion is removed
Why should people who have acid secretion problems not eat a lot of protein?
→it causes acid hypersecretion
What do neuronal inputs promote in gastrin release?
→ACh mediated acid secretion
→stimulation of acid called GRP (gastrin releasing peptide)