Transplantation

Question 1

2 sources of donor kidneys

Answer 1

live and deceased

Question 2

2 types of deceased donors

Answer 2

brain dead

cardiac death

Question 3

define autograft

Answer 3

self transferred from one body site to another in the same individual

Question 4

define isograft

Answer 4

tissue transferred between genetically identical individuals

Question 5

define allograft

Answer 5

tissue transferred between genetically different members of the same species

Question 6

define xenograft

Answer 6

from different species

Question 7

4 types of graft

Answer 7

autograft
isograft
allograft
xenograft

Question 8

4 categories of cellular components of immune system

Answer 8

APCs
B cells and antibodies
T cells
Other cells

Question 9

4 effector mechanisms of allogeneic grafts

Answer 9

cell mediated
humoral mediated
direct recognition
indirect recognition

Question 10

5 mechanisms for overcoming the immune response

Answer 10

Total body irradiation
Surgical ablation 
Total lymphoid irradiation (also take out spleen)
Immunosuppressive drugs
Immunoabsorption/ plasmapheresis

Question 11

what type of drug is cyclosporin?

Answer 11

calcineurin inhibitor

Question 12

3 examples of immunosuppressive drugs used in renal transplants

Answer 12

cyclosporin
tacrolimus
azathioprine
prednisolone

Question 13

When does acute rejection occur?

Answer 13

in first 3 months

Question 14

2 types of acute rejection

Answer 14

2 types of rejection- cellular or vascular (blockage of blood supply)

Question 15

adverse complications of immunosuppression

Answer 15

infection

malignancy

Question 16

4 viruses that people who are immunosuppressed are susceptible

Answer 16

HSV
CMV
VZV
EBV