Transplant/Immunology Flashcards
Which antibody is mucosal?
IgA
MucosAAAAAAA
Which antibody for breast milk?
IgA
Which antibody signifies past infection?
IgG
These are the OG antibodies who fought in the original war
Which antibody is produced first to new infection?
IgM
IMMMediate antibodies
Rx for acute humoral rejection?
Humoral: B cell mediated -> antibodies
Plasmapheresis
IVIg
Rituximab (antiCD20)
How does chronic rejection manifest in heart?
Vasculopathy + accelerated atherosclerosis
How does chronic rejection manifest in liver?
Vanishing bile duct syndrome
How does chronic rejection manifest in lung?
Bronchiolitis obliterans
How does chronic rejection manifest in kidney?
Interstitial fibrosis and tubular atrophy
Explain sensitization, PRA (Panel reactive antibody), and DSA (Donor specific antibody) in layman’s terms
Sensitization: pre-formed antibodies. The potential txp recipient already has antibodies (from pregnancy, transfusions, and previous transplants)
PRA: let’s say the potential recipient has antibodies against X. PRA is- what % of the population has the antigen X?
DSA: is how potent is the antibody reaction for those antibodies?
Which immunosuppressant is classically associated with seizures and tremors?
FK506 (Tacrolimus)
Immunosuppressant with poor wound healing?
Rapamune»_space; prednisone
Which immunosuppressant can cause gingival hypertrophy and hirsutism?
Cyclosporine
What are the old and new clacineurin inhibitors?
New: FK506 (prograf)
old: cyclosporine (hirsutism)
You get levels for both of these remember?
Old and new antiproliferative immunosuppressant?
Old: azathioprine
New: mycophenolate
Which immunosuppressant can cause leukopenia?
MMF
Which immunosuppressant can cause horrible GI toxicity?
MMF
When is a panc alone txp indicated?
Which one is almost always better pancreas alone or spk?
Hypoglycemic unawareness
Spk is almost always better
Most common cause of death after liver transplantation?
Infection
Most common underlying issue for bile duct problems after liver txp?
Issue with the hepatic artery
What is the official definition of delayed graft function after kidney transplant?
What is the incidence?
Requirement of dialysis in the first week after transplant
15-30% of deceased kidney txp
What’s the advantage of bladder drainage in pancreas transplant?
You can monitor fx by amylase and stuff
Virus responsible for post-transplant cervical cancer?
HPV
Virus responsible for post-transplant lymphoproliferative disorder?
EBV
Virus responsible for post-transplant liver cancer?
Hep B, hep C
Virus responsible for post-transplant kaposi sarcoma
HSV8