Transplant

Question 1

What is the definition of death for the organ procurement process?

Answer 1

1. irreversible cessation circulatory & respiratory function
2. irreversible cessation of all functions of entire brain, including brainstem

Question 2

allograft (homograft)

Answer 2

from the same species, non identical

Question 3

isograft (syngeneic)

Answer 3

identical twin

Question 4

autograft transplant

Answer 4

tissue transplanted from one site to another

Question 5

xenograft (heterograft)

Answer 5

between two species

Question 6

How long can the:
heart & lungs
kidney
liver 
survive outside body?

Answer 6

Heart & lungs - 4 - 6 hours
Kidney - 36 - 48 hours
Liver - 12 - 15 hours

Question 7

Host Vs. Graft

Answer 7

host attacks organ being put in

- most types of rejection are this

Question 8

Graft vs. Host

Answer 8

more common with hematopoietic transplant (b/c we put in immune system –> attacking host)

Question 9

What is the order of strictness for protective precautions? (most strict –> least strict)

Answer 9

lung –> heart –> kidney/liver

Question 10

After a hematopoietic cell transplant, how long is someone immuno-compromised?

Answer 10

6 months to 1 year

Question 11

Innate Immunity

Answer 11

• “nonspecific”
• general type
• 1st line of defense
• regulation of inflammation
• > 90% of infections are controlled by this type of immunity
• fever & inflammation

Question 12

Adaptive Immunity

Answer 12

• specific or acquired
• 2nd line of defense
• has a “memory”; refines and adjusts over lifetime of host
• humoral and cell-mediated

Question 13

Colonization

Answer 13

microbes present in skin/mucous membrane without signs & symptoms of active infection

Question 14

Neutropenia

Answer 14

low # of neutrophils in blood = higher risk for acquiring infections