Translation/transcription factors Flashcards
1
Q
eIF2B
A
translational control: brings met-tRNAi to 40S, eIF2B phosphorylation inhibits translation –> mutation causes Vanishing white matter
2
Q
eIF4E
A
translational control: binds the mRNA 5’ cap and is part of scanning complex, phosphorylation of eIF4E or E4-BP increases its function and overall translation
3
Q
eIF4G
A
Poliovirus cleaves eIF4G, which still works for poliovirus IRES-mediated initiation
4
Q
eEF1
A
translational control: supplies aa-tRNA to ribosome during elongation
5
Q
eEF2
A
the Diphtheria toxin ADP-ribosylates eEF2 causing its inactivation, inhibiting translocation
6
Q
TFIIH
A
Has helicase and kinase activity -> it phosphorylates the CTD of RNA polymerase II, starting transcription
