Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CMB > Translation > Flashcards

Translation Flashcards

1
Q

Translation in Prokaryotes Step 1

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Translation in Prokaryote Step 2

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Translation in Prokaryote Step 3

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Closed Loop Model of Eukaryotic Translation

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Translocation of Ribosome Down the mRNA transcript

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the three roles of the release factor

A

Hydrolysis of the terminal peptidyl bond,

release of the polypeptide and tRNA

dissociation of the ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Puromycin

A

premature chain termination by acting as an analog of aa-tRNA

ribosome can’t translate which leads to dissociation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

tetracyclins

A

blocks the A site on 30S subunit and inhibits binding of aminoacyl tRNAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chloramphenicol

A

inhibits peptidyl transferase (prokaryotes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cycloheximide

A

inhibits peptidyl transfease in eukaryotes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

streptomycin

A

inhibits initiation and causes misreading of mRNA in prokaryotes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

diptheria toxin

A

inactivates eukaryotic eEF3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ricin

A

inactivate the 60S subunit of the eukaryotic ribosome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are consensus properties of signal sequences directed to the ER?

A

stretch of hydrophobic amino acids

one or more positively charged residues preceding hydrophobic sequence

some polar amino acids and short side chains near cleavage site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 8 steps that take a protein from free ribosomes to the ER?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The ER Gylcosylation pathway

A

Core oligosaccharide is attached to dolichol phosphate and core is built up on cytosolic face of ER

oligosaccharide translocated across ER

other mannose or glucose residues may be added to oligo

In N-linked proteins transferase moves oligosaccharide to asn residue

oligosaccharide is modified and dolichol phosphate carrier molecule is recycled

17
Q

Transport to Mitochondria

A

N-Terminal Signal Sequence bound by HSP 70 and MSF

(mostly ser thr and basic residues)

Precursor is delivered to receptor and then transferred inside via mHSP70 and electrochemical potential

signal sequence is removed and protein is refolded

18
Q

Transport to the Nucleus

A
19
Q

Polyubiquitination

A
20
Q

Protein targeting in Prokaryotes

A
21
Q

ER Glycosylation (picture)

A

CMB (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions