transition from academia to reseach

Question 1

what are the 4 stages of research

Answer 1

-basic science
-translational research
-efficacy study
-outcomes and effectibeness research

Question 2

what do you need to start a lab

Answer 2

 A good project
 Your own ideas
 Funding

Question 3

what do you need to survive to survive running an academic lab

Answer 3

More funding
 Great graduate students and post-docs
 New ideas
 Innovation
 Collaborations (academic and industry)

Question 4

true or false: in running an academic lab you are the boss

Answer 4

yeah

Question 5

true or false: grant funding rates keep going lower

Answer 5

true

Question 6

running an industry lab: what u need to start

Answer 6

-Drive to make a difference
 Flexibility
 Patience

Question 7

running an industry lab: what u need to survive

Answer 7

 A great research team
 New ideas
 Innovation
 More patience
 Adaptability
 Collaboration

Question 8

running an industry lab, you decide what

Answer 8

 who you hire
 how projects progress (with boss)
 priorities
 which projects to stop (not always)
 who to collaborate with or not

Question 9

what are the 3 hats that a pi wears in an industry lab

Answer 9

-Principle investigator
 Writer / editor
 Committee member

Question 10

Lead discovery then seeks to identify a drug-like small molecule termed a …..

Answer 10

development candidate that will progress into preclinical and then clinical development

Question 11

what are the main reasons for rnd failure

Answer 11

-thoxology/safety issues
-lack of efficacy
-pharmacokinetics
-commercial reasons

Question 12

what do biologists do in rnd

Answer 12

 Develop assays and reagents
 Explore target biology and MOA
 Test compounds in relevant in vitro assays

Question 13

what do pharmacologist do in rnd

Answer 13

test compounds in relevant in vivo models

Question 14

what do medicinal chemists do in rnd

Answer 14

make tool compounds needed for in vitro and in vivo testing

Question 15

what do analytical chemists do in rnd

Answer 15

evaluate the physiochemical and pharmokinetics of compounds

Question 16

In industry you will

Answer 16

-Be required to work within the business and scientific strategy of the company and not be solely guided by your own scientific interests
 Be asked to pivot to new projects quickly
 Be required to participate in and present at cross-functional meetings where data is vetted, and the future directions of a project are established by
discussion and consensus

Question 17

true or false: biotech is usually more innovative, high-risk scientific approaches

Answer 17

true while big pharma is usually more of a pussy behavior

Question 18

true or false: big pharma is usually more hierarchical

Answer 18

true biotech is more chill

Question 19

true or false: in biotech they have more resources than Academia, but often
partners with Pharma for expensive late-stage
clinical programs

Answer 19

true

Question 20

true or false: big p0harma can be aquiried and have periodic layoffs

Answer 20

true
but more stable usually

Question 21

true or false: in biotech more opportunities for advancement than Academia or Pharma if company grows

Answer 21

true
-Stock options can provide financial windfall if
company successful

Question 22

true or false: in big pharma it takes longer to have a promotion

Answer 22

true