Lecture 15

Question 1

what is paraza

Answer 1

-mtl canada based, fully integrated preclinical drug discovery company committed to the discovery and delivery drug candidates for client partners

Question 2

when was paraza was established

Answer 2

2011

Question 3

scientific areas of expertise within paraza

Answer 3

-chemical sciences
-biology
-drug metabolism and pharmacokinetics (DMPK)

Question 4

true or false: most biotech companies get to clinical trials

Answer 4

false: most don’t have enough money so the biotechs give the license to pharma to do the trials

Question 5

biotech companies are funded by investors which are typically what ?

Answer 5

venture capital companies

Question 6

how do biotech companies get money after being funded by venture capital companies

Answer 6

they get a payout when projects are licensed ot the company enters the stock market or is purchased

Question 7

true or false: most biotech companies brought products all the way to market and then become pharma companies like gilead, amgen, biogen

Answer 7

false: a few companies

Question 8

pharmaceutical companies ern income from what?

Answer 8

-portfolio of marketed products and invest some profits in r&d

Question 9

r&d historically performed where

Answer 9

in-house from target id through product lunch

Question 10

today both pharma and biotechs outsource most or their r&d to what

Answer 10

contract research organizations aka CROs

Question 11

what is a cro

Answer 11

-a company that provide services to biotechs and pharma companies
-work is performed for immediate payment rather than as investment for future profit from sales

Question 12

true or false: a cro needs to be a big company

Answer 12

nah usually it can start as small and then grow as a business develops

Question 13

how many cros in canada and mtl

Answer 13

-850 in canada
-200 located in mtl area

Question 14

true or false: only biotechs use cros

Answer 14

nah pharma usually can also use cro
-some cros in india and china make whole ass buildings to house hundreds of employees dedicated to one company

Question 15

true or false: big biotechs are the ones that use the most cros

Answer 15

nah usually it is small biotechs
-they usually have more dry lab things and they use cros for wet lab

Question 16

true or false: cros are more expensive for biotechs

Answer 16

nah cros are less expensive and faster because you already have the space for the employees
-also some companies have like a chemistry department but not a bio department

Question 17

what is the biggest departmnet at saraza

Answer 17

medical chemistry department

Question 18

true or false: the chemical development dep makes small quantities

Answer 18

false: they make a shit ton of chemicals

Question 19

chemical department expertise

Answer 19

-api synthesis
-natural products and analogs
-stable label isotopes
-fluo dyes
-electrochemical transformation
-peptide and parallel synthesus

Question 20

medical chemistry in sarasa

Answer 20

-non classical modalities

Question 21

true or false: saraza uses computers in medical chemistry

Answer 21

-yeah computer aided drug design

Question 22

true or false: the bio dep in saraza are specialized in in vitro pharmacology

Answer 22

false: in vivo pharmacology

Question 23

what does dmpk dep do in pharmacology

Answer 23

-in vitro
-in vivo
-bioanalysis
-tailored adme screening

Question 24

what are the core paraza capabilities and expertise

Answer 24

-target id and validation
-hit identification
-lead identification
-lead optimization
-candidate selection

Question 25

what are the resourcing models of saraza

Answer 25

-full time equivalent
-fee for service

Question 26

full time equivalent: FTE

Answer 26

-fixed monthly cost per person working on the project
-assigned employees are 100% dedicated to their projects
-most chemists and biologists at paraza are working on a FTE basis
-many of ongoing projects are fully integrated with FTE in both departments

Question 27

what is fee for service

Answer 27

-a pre agreed fee is charged for a defined task
-dmpk is based on the ffs model
-can be favored approach for smth in chemistry and bio:
-specific compound synthesis
-in vivo pharmacology
-screening s using a previously validated assay