Transient Ischemic Attack Flashcards

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1
Q

What are Transient ischemic attacks characterized by?

A

focal ischemic cerebral neurologic deficits that last for < 24 hours

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2
Q

How long does a TIA usually last?

A

less than 1-2 hours

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3
Q

__% of patients with stroke have a history of transient ischemic attacks

A

30%

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4
Q

What is an important cause of TIA?

A

embolization

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5
Q

What 2 locations are emboli apparent?

A
  • heart

- extracranial arteries

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6
Q

What are the cardiac causes of embolic ischemic attacks?

A
  • atrial fibrillation
  • rheumatic heart disease
  • mitral valve disease
  • infective endocarditis
  • atrial myxoma
  • mural thrombi complicating myocardial infarction
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7
Q

What are paradoxical emboli?

A

Emboli that travel from the veins to the brain through atrial septal defects and patent foramen ovale

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8
Q

An ____ plaque on a major artery to the brain may also serve as a source of emboli

A

ulcerated

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9
Q

Where is atherosclerosis most commonly seen? What does this cause?

A

in the Carotid bifurcation extracranially

causes a bruit

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10
Q

Patients with what disease have an increased risk of developing transient ischemic deficits or strokes?

A

AIDS

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11
Q

What are 4 other less common abnormalities of blood vessels that may cause a TIA?

A
  • Fibromuscular dysplasia
  • atherosclerosis of the aortic arch
  • inflammatory arterial disorders such as giant cell arteritis, SLE, polyarteritis, and granulomatous angiitis
  • Meningovascular syphilis
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12
Q

Although hypotension may cause a reduction of cerebral artery blood flow if a major extracranially artery to the brain is stenosed, this is a ____ source of TIA

A

rare

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13
Q

Other than what has already been listed, list 4 other disorders that can cause a TIA

A
  • polycythemia
  • sickle cell disease
  • hyperviscosity syndromes
  • severe anemia
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14
Q

Subclavian ____ syndrome may lead to transient vertebrobasilar ischemia.

A

steal

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15
Q

When do symptoms of subclavian steal syndrome arise?

A

When there is localized stenosis or occlusion of one subclavian artery proximal to the source of the vertebral artery, so that blood is “stolen” from it.

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16
Q

What are the signs and symptoms of subclavian steal syndrome?

A
  • bruit in the supraclavicular fossa
  • unequal radial pulses
  • difference of 20 mm Hg or more between the systolic blood pressures in the arms
17
Q

What do specific symptoms of a TIA depend on?

A

the arterial distribution affected

18
Q

The risk of stroke is high in the first _ months after an attack, particularly in the _ month and especially within the first __ hours

A

3

first

48

19
Q

There is a higher risk for stroke with what type of attack?

A

carotid ischemic attacks

20
Q

Stroke risk is greatest in patients __ years of older and those who have ______.

A

60

diabetes

21
Q

Stroke risk is greatest after transient ischemic attacks that last longer than __ minutes and with symptoms or signs of weakness, speech impairment, or gait disturbance.

A

10

22
Q

What imaging technique is indicated within the first 24 hours of symptom onset?

A

CT and MRI

23
Q

What type of MRI is particularly sensitive for revealing acute or subacute infarction?

A

MRI with diffusion-weighted sequences

24
Q

What imaging technique is especially useful for detecting significant stenosis of the internal carotid artery?

A

carotid duplex ultrasonography

25
Q

What does an invasive cerebral arteriography allow for?

A

angioplasty or other interventions if necessary

26
Q

____ monitoring is indicated id a transient, paroxysmal disturbance of cardiac rhythm is suspected

A

Holter

27
Q

What are the 3 differential diagnoses of TIA?

A
  • Focal seizures
  • Classic migraine
  • Focal neurological deficits due to hypoglycemia
28
Q

What is a commonly used method to assess recurrence risk?

A

ABCD2 score

29
Q

An ABCD2 score of _ or more points has been suggested as a threshold for hospital admission.

A

3

30
Q

What is medical treatment aimed at?

A

preventing further attacks and stroke

31
Q

When treating causes such as diabetes mellitus, hematologic disorders, and hypertension what medication is typically preferred?

A

an angiotensin-­converting enzyme inhibitor or angiotensin receptor blocker

32
Q

What other drug should also consider being started?

A

statins

33
Q

What are 3 lifestyle changes that patients should adopt?

A
  • Smoking cessation
  • Weight reduction
  • Regular physical activity
34
Q

When is cardioembolism from the heart an indication for anticoagulation as a preventive treatment for stroke?

A

When is in the setting of atrial fibrillation

35
Q

What drugs are indicated for the treatment of embolism from the heart?

A

anticoagulants

36
Q

List the 4 drugs prescribed in noncardiacembolic attacks

A
  • Low-dose aspirin (81 mg)
  • Dipyridamole
  • Clopidegrol
  • Cilostazol
37
Q

When are surgical or endovascular measures indicated?

A

When arteriography reveals a surgically accessible high grade stenosis (70-99% in luminal diameter)

38
Q

Surgical or endovascular measures have moderate benefit is patients with __-__% stenosis and no benefit in mild stenosis less than __%

A

50-69

50