Transfusion Medicine Flashcards

1
Q

What is blood compatibility based on?

A

Protection of the RBC from destruction by an antibody

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2
Q

What is plasma compatibility based on?

A

Donor plasma antibody

E.g. cannot give B plasma to A patient b/c B plasma has anti-A

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3
Q

What is the purpose of packed red blood cells and what are they indicated for?

A

Increase blood oxygen carrying capacity

Used in symptomatic anemia

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4
Q

What is important to remember about the administration of PRBC?

A

Can only add normal saline to PRBC or run normal saline through IV with PRBC

No medication or other solutions

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5
Q

What are the indications for frozen RBCs?

A

Autologous units

Rare blood types

IgA deficient recipients

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6
Q

What are washed RBCs and their indications?

A

RBCs washed in normal saline

IgA deficiency and allergic reactions to plasma proteins

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7
Q

What is the shelf life of washed RBCs after washing?

A

24 hours

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8
Q

What are the two types of platelets?

A

Random donor platelets from a single unit of blood

Platelet apheresis (single donor platelets: equal to 6 random donor platelets

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9
Q

How much will a 6 pack of random donor or single apheresis platelets raise platelet count?

A

30K

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10
Q

What are the indications for platelet use?

A

Thrombocytopenia

Bleeding without thrombocytopenis (function disorder)

Massive transfusion

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11
Q

What is platelet refractory and what are the causes?

A

Patient does not increase platelets after transfusion

Splenomegaly

Accelerated consumption (DIC, bleeding)

Alloimmuniation (anti-HLA antibodies destroy platelets)

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12
Q

What are leukoreduced platelets and PRBCs and what are their advanatges?

A

Processing of these products greatly reduces WBC content

Decreased incidence of alloimmunization against WBC antigens (HLA)

Decreased risk of CMV transmission

Decreased risk of febrile nonhemolytic transfusion reaction

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13
Q

What are the indications for FFP/FP24?

A

Significant bleeding with coagulation factor deficiency

Correction of PTT or PT in preop setting

Thrombotic thrombocytopenic purpura

Massive transfusion

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14
Q

What are the inappropriate uses for FFP/FP24?

A

Volume expansion

Coagulation factor replacement if other options are available

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15
Q

What are the contents of cryoprecipitate?

A

Fibrinogen

vWF

Factor VIII

Factor XIII

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16
Q

What is the indication for cryoprecipitate?

A

Fibrinogen replacement

17
Q

In what situation would you crossmatch a patients blood after a type and screen?

A

If the antibody screen is positive