Transfusion Medicine Flashcards
What is blood compatibility based on?
Protection of the RBC from destruction by an antibody
What is plasma compatibility based on?
Donor plasma antibody
E.g. cannot give B plasma to A patient b/c B plasma has anti-A
What is the purpose of packed red blood cells and what are they indicated for?
Increase blood oxygen carrying capacity
Used in symptomatic anemia
What is important to remember about the administration of PRBC?
Can only add normal saline to PRBC or run normal saline through IV with PRBC
No medication or other solutions
What are the indications for frozen RBCs?
Autologous units
Rare blood types
IgA deficient recipients
What are washed RBCs and their indications?
RBCs washed in normal saline
IgA deficiency and allergic reactions to plasma proteins
What is the shelf life of washed RBCs after washing?
24 hours
What are the two types of platelets?
Random donor platelets from a single unit of blood
Platelet apheresis (single donor platelets: equal to 6 random donor platelets
How much will a 6 pack of random donor or single apheresis platelets raise platelet count?
30K
What are the indications for platelet use?
Thrombocytopenia
Bleeding without thrombocytopenis (function disorder)
Massive transfusion
What is platelet refractory and what are the causes?
Patient does not increase platelets after transfusion
Splenomegaly
Accelerated consumption (DIC, bleeding)
Alloimmuniation (anti-HLA antibodies destroy platelets)
What are leukoreduced platelets and PRBCs and what are their advanatges?
Processing of these products greatly reduces WBC content
Decreased incidence of alloimmunization against WBC antigens (HLA)
Decreased risk of CMV transmission
Decreased risk of febrile nonhemolytic transfusion reaction
What are the indications for FFP/FP24?
Significant bleeding with coagulation factor deficiency
Correction of PTT or PT in preop setting
Thrombotic thrombocytopenic purpura
Massive transfusion
What are the inappropriate uses for FFP/FP24?
Volume expansion
Coagulation factor replacement if other options are available
What are the contents of cryoprecipitate?
Fibrinogen
vWF
Factor VIII
Factor XIII